SARGUEIL Bruno : UMR8015 : Mécanismes Moléculaires de l'Initiation de la Traduction

Unit : CNRS UMR8015 - Paris Descartes University

Faculty of Pharmaceutical and Biological Sciences
Laboratory of Crystallography and NMR
4 av. de l'Observatoire
75270 Paris Cedex 06

Speciality : Biochemistry , Molecular Biology , Structural Biology , Microbiology , Molecular modeling

Director of the unit : Nicolas LEULLIOT

Principal investigator :

SARGUEIL Bruno
Email : bruno.sargueilSPAMFILTER@parisdescartes.fr Phone number: 01 53 73 15 68

Composition of research team :

  • CHAMOND Nathalie (CR-CNRS)
  • PONCHON Luc (MC, HDR)
  • SARGUEIL Bruno (DR-CNRS, HDR)

5 Recent publications of the research team :

Portoso M, Ragazzini R, Brencic Z, Moiani A, Michaud A, Vassilev I, Wassef M, Servant N, Sargueil B, Margueron R (2017) PRC2 is dispensable for HOTAIR-mediated transcriptional repression. Embo J In Press

Angulo J, Ulryck N, Deforges J, Chamond N, Lopez-Lastra M, Masquida B, Sargueil B (2016) LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Nucleic Acids Res 44: 1309-1325

Deforges J, Locker N, Sargueil B (2015) mRNAs that specifically interact with eukaryotic ribosomal subunits. Biochimie 114: 48-57

Chamond N, Deforges J, Ulryck N, Sargueil B (2014) 40S recruitment in the absence of eIF4G/4A by EMCV IRES refines the model for translation initiation on the archetype of Type II IRESs. Nucleic Acids Res 42: 10373-10384

Chazal PE, Daguenet E, Wendling C, Ulryck N, Tomasetto C, Sargueil B, Le Hir H (2013) EJC core component MLN51 interacts with eIF3 and activates translation. Proc Natl Acad Sci U S A 110: 5903-5908