VIGNUZZI Marc : Institut Pasteur : Viral populations and Pathogenesis Unit (PVP)

Unit : Département de Virologie - Institut Pasteur

Institut Pasteur
Unité de Populations virales et pathogenèse
28 rue du Docteur Roux
75724 PARIS Cedex

Speciality : Department IM

Director of the unit : Olivier SCHWARTZ

Principal investigator :

Email : Phone number: +33 (0)1 45 68 82 42

Composition of research team :


5 Recent publications of the research team :

Levi LI, Gnadig NF, Beaucourt S, McPherson MJ, Baron B, England P, Arnold JJ, Vignuzzi M*. (2010) Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds. PLOS Pathogens 6(10): e1001163.

Coffey LL and Vignuzzi M*. (2011) Host alternation of chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures. Journal of Virology, Jan;85(2):1025-35.

Coffey LL,  Beeharry Y, Bordería AV, Blanc H. and Vignuzzi M*. (2011) Arbovirus high fidelity variant loses fitness in mosquitoes and mice. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16038-43.

Gnädig NF, Beaucourt S, Campagnola G, Bordería AV, Sanz-Ramos M, Gong P, Blanc H, Peersen O, Vignuzzi M* (2012). Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):E2294-303.

Smith C, Blanc H, Vignuzzi M and Denison M. (2013) Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics. PLOS Pathogens, 2013 Aug;9(8):e1003565.