CLAVEL François : UNM_S941 : Viral Genetics and Pathogenesis of viral disease

Unit : INSERM UMR_S941 Génétique des Virus et Pathogénèse des Maladies Virales Université Paris Diderot

Institut Universitaire d'Hématologie
INSERM UMR_S941 "Génétique des Virus et Pathogénèse des Maladies Virales"
Bâtiment HAYEM - Hôpital Saint-Louis
1 avenue Claude Vellefaux
75475 PARIS Cedex 10

Speciality : Department IM

Director of the unit : CLAVEL François

Principal investigator :

CLAVEL François
Email : francois.clavelSPAMFILTER@inserm.fr Phone number: +33 (0)1 57 27 64 64

Composition of research team :

  • CLAVEL François  (PU-PH, HDR)
  • SIMON  François (PU-PH, HDR)
  • HANCE Allan  (DR1-INSERM, HDR)  
  • LEGOFF Jérôme (MCU-PH , HDR)
  • ARHEL Nathalie  (CR1 CNRS, HDR)

5 Recent publications of the research team :

Fernandez J, Portilho DM, Danckaert A, Munier S, Becker A, Roux P, Zambo A, Shorte S, Jacob Y, Vidalain PO, Charneau P, Clavel F, Arhel NJ. Microtubule-Associated Proteins 1 (MAP1) Promote Human Immunodeficiency Virus Type I (HIV-1) Intracytoplasmic Routing to the Nucleus. J Biol Chem. 2014 Dec 11. pii: jbc.M114.613133

Takeuchi JS, Perche B, Migraine J, Mercier-Delarue S, Ponscarme D, Simon F, Clavel F, Labrosse B. High level of susceptibility to human TRIM5α conferred by HIV-2 capsid sequences. Retrovirology. 2013 May 6;10:50.

Di Nunzio F, Danckaert A, Fricke T, Perez P, Fernandez J, Perret E, Roux P, Shorte S, Charneau P, Diaz-Griffero F, Arhel NJ. Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One. 2012;7(9):e46037.

Lelek M, Di Nunzio F, Henriques R, Charneau P, Arhel N, Zimmer C. Superresolution imaging of HIV in infected cells with FlAsH-PALM. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8564-9.

Dam E, Quercia R, Glass B, Descamps D, Launay O, Duval X, Kräusslich HG, Hance AJ, Clavel F; ANRS 109 Study Group. Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss. PLoS Pathog. 2009 Mar;5(3):e1000345.