GOURDON Geneviève : UMR_S1163 : Unstable CTG repeat and myotonic dystrophy

Unit : INSERM UMR_S1163 -IHU Imagine - Institut des Maladies Génétiques - Université Paris Descartes

IHU Imagine - Institut des Maladies Génétiques
Bâtiment Imagine
Laboratoire “Triplets CTG instables et dystrophie myotonique” 
24 Boulevard du Montparnasse
75015 PARIS

Speciality : Department DGNRV

Director of the unit : Alain FISCHER

Principal investigator :

GOURDON Geneviève
Email : gourdon.genevieveSPAMFILTER@inserm.fr Phone number: +33 (0)1 42 75 43 43

Composition of research team :

  • GOURDON Geneviève (DR2-INSERM, HDR)
  • TOME Stéphanie (CR2-INSERM)

5 Recent publications of the research team :

Hernandez-Hernandez O, Guiraud-Dogan C, Sicot G, Huguet A, Luilier S, Steidl E, Saenger S, Marciniak E, Obriot H, Chevarin C, Nicole A, Revillod L, Charizanis K, Lee KY, Suzuki Y, Kimura T, Matsuura T, Cisneros B, Swanson MS, Trovero F, Buisson B, Bizot JC, Hamon M, Humez S, Bassez G, Metzger F, Buée L, Munnich A,  Sergeant N, Gourdon G, and Gomes-Pereira M. Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behavior Brain, 2013 136(Pt 3):957-70

Huguet A, Medja F, Nicole A, Vignaud A, Guiraud-Dogan C, Ferry A, Decostre V, Hogrel JY,Metzger F, Hoeflinch A, Baraibar M, Gomes-Pereira M, Puymirat J, Bassez G, Furling D, Munnich A and  Gourdon G. Molecular defects and motor performance abnormalities in the DMSXL mouse model for myotonic dystrophy. PloS Genetics, 2012 Nov;8(11):e1003043

Tomé S, Holt I, Edelmann W, Morris G, Munnich A, Pearson CE  and Gourdon G. MSH2 ATPase domain mutation affects CTG•CAG repeat instability in transgenic mice. PloS Genetics 2009, May;5(5):e1000482.

Gomes-Pereira M, Foiry L, Nicole A, Huguet A, Junien C, Munnich A and Gourdon G. CTG trinucleotide repeat “big jumps”: large expansions, small mice. PloS Genetics, 2007 6;3(4):e52

Savouret C, Brisson E, Essers J, Kanaar R, Pastink A, te Riele H, Junien C and Gourdon G. CTG repeat instability and size variation timing in repair-deficient mice. The Embo Journal, 2003, 22 :2264-2273.