van der WERF Sylvie : Institut Pasteur : Unit of Molecular Genetics of RNA Viruses (CNRS UMR3569) Université Paris Diderot

Unit : Département de Virologie - Institut Pasteur

Institut Pasteur
Unité de Génétique Moléculaire des Virus à ARN (CNRS UMR 3569)
25 rue du Docteur Roux
75724 PARIS Cedex 15

Speciality : Department IM

Director of the unit : Olivier SCHWARTZ

Principal investigator :

van der WERF Sylvie
Email : Phone number: +33 (0)1 45 68 87 22/25

Composition of research team :

  • van der WERF Sylvie (PR, HDR)
  • NAFFAKH Nadia (DR2-CNRS, HDR)     
  • MARTIN Annette (CR-IP, HDR)   
  • JACOB Yves  (CR-IP, HDR)  
  • DEMERET Caroline (CR-IP, HDR)    
  • COHEN Lisette (MCF, HDR)
  • MUNIER Sandie (MCF)
  • CRESCENZO-CHAIGNE Bernadette  (Ingénieur IP)   
  • CASSONNET Patricia (Ingénieur IP)

5 Recent publications of the research team :

Munier S, Rolland T, Diot C, Jacob Y, Naffakh N. (2013) Exploration of binary virus-host interactions using an infectious protein complementation assay. Mol Cell Proteomics.  doi 10.1074/mcp.M113.028688. Epub 2013/07/03

Guery B, Poissy J, el Mansouf L, Séjourné C, Ettahar N, Lemaire X, Vuotto F, Goffard A, Behillil S, Enouf V, Caro V, Mailles A, Che D, Manuguerra JC, Mathieu D, Fontanet A, van der Werf S; MERS-CoV study group. (2013) Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission. Lancet. 29;381(9885):2265-72.

Moisy D, Avilov SV, Jacob Y, Laoide BM, Ge X, Baudin F, Naffakh N, Jestin JL. (2012). HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication. J Virol. 86(17):9122-33

LeGoff J, Rousset D, Abou-Jaoudé G, Scemla A, Ribaud P, Mercier-Delarue S, Caro V, Enouf V, Simon F, Molina JM, van der Werf S. (2012)  I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y. PLoS One. 7(8):e37095.

Benureau, Y., Warter, L., Malcolm, B.A., and Martin, A. (2010). A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication. Virology, 406, 227-239