EL BENNA Jamel : UMR_S11149 ERL8252 : Team "Phagocytes, NADPH Oxidases and Immunogenetics in Systemic Inflammation"

Unit : INSERM UMR_S1149 CNRS ERL 8252 Centre de Recherche sur l'Inflammation (CRI) Université Paris Diderot

Centre de recherche sur l’inflammation CRI
Faculté de Médecine  Xavier Bichat
16 Rue Henri Huchard
75018 PARIS

Speciality : Department IMMUNO

Director of the unit : Renato MONTEIRO

Principal investigator:

EL BENNA Jamel
Email : jamel.elbennaSPAMFILTER@inserm.fr Phone number: +33 (0)1 57 27 77 23

Composition of research team :

  • EL BENNA Jamel (DR-CNRS, HDR)
  • CHASTRE Chastre Eric (CR-INSERM, HDR)
  • DANG  Pham My-Chan (CR-CNRS, HDR)  
  • DIEUDE Philippe (PU-PH, HDR)
  • HURTADO-NEDELEC Margarita (MCU-PH) 
  • MARIE Jean-Claude (CR-INSERM, HDR) 
  • MEYER Olivier (PU-PH, HDR)
  • PERIANIN Axel (DR-CNRS, HDR)    
  • WALKER Francine (MCU-PH, HDR)

5 Recent publications of the research team :

Rolas L, Makhezer N, Hadjoudj S, El-Benna J, Djerdjouri B, Elkrief L, Moreau R, Périanin A. (2013 Mar) Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis. Hepatology.;57(3):1163-71.

Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, Hayem G, Gougerot-Pocidalo MA, Frystyk J, Flyvbjerg A, El Benna J, Marie JC. (2012 Feb). Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes. Am J Pathol.;180(2):682-92.

Makni-Maalej K, Boussetta T, Hurtado-Nedelec M, Belambri SA, Gougerot-Pocidalo MA, El-Benna J. (2012 Nov). The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol.1;189(9):4657-65.

Dieudé P, Guedj M, Truchetet ME, Wipff J, Revillod L, Riemekasten G, Matucci-Cerinic M, Melchers I, Hachulla E, Airo P, Diot E, Hunzelmann N, Mouthon L, Cabane J, Cracowski JL, Riccieri V, Distler J, Amoura Z, Valentini G, Camaraschi P, Tarner I, Frances C, Carpentier P, Brembilla NC, Meyer O, Kahan A, Chizzolini C, Boileau C, Allanore Y (2011 Apr). Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. Arthritis Rheum.;63(4):1097-105.

Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, Raad H, Arabi Derkawi R, Bournier O, Kroviarski Y, Zhou XZ, Malter JS, Lu PK, Bartegi A, Dang PM, El-Benna J (2010 Dec). The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. Blood. 23;116(26):5795-802.