MALLONE Roberto & YOU Sylvaine : T-cell tolerance, biomarkers and therapies in type 1 diabetes (DeARLab) : T-cell tolerance, biomarkers and therapies in type 1 diabetes (DeARLab) UMR_S1016 CNRS8104 Institut Cochin

Unité de recherche : UMR_S1016 CNRS8104 Institut Cochin

Institut COCHIN

Bâtiment Cassini, 3ème étage

123 Bd de Port Royal, 75014 Paris

Speciality : Department IMMUNO

Directeur de l'unité de rattachement : Pierre-Olivier COURAUD

Responsable de l'équipe de recherche : MALLONE Roberto & YOU Sylvaine

MALLONE Roberto & YOU Sylvaine
Email : roberto.malloneSPAMFILTER@inserm.fr Phone number: 01 76 53 55 83 (ou 89)

Composition de l'équipe de recherche :

  • R. Mallone, DR1 Inserm (Co-directeur)
  • S. You, CR1 Inserm (Co-directrice)
  • D. Dubois-Laforgue, MCU-PH

5 publications récentes de l'équipe de recherche :

1. S. Gonzalez-Duque, M.E. Azoury, M.L. Colli, G. Afonso, J.V. Turatsinze, L. Nigi, A.I. Lalanne, G. Sebastiani, A. Carré, S. Pinto, S. Culina, N. Corcos, M. Bugliani, P. Marchetti, M. Armanet, M. Diedisheim, B. Kyewski, L.M. Steinmetz, S. Buus, S. You, D. Dubois-Laforgue, E. Larger, J.P. Beressi, G. Bruno, F. Dotta, R. Scharfmann, D.L. Eizirik, Y. Verdier, J. Vinh, R. Mallone. Conventional and neo-antigenic peptides presented by beta cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors. Cell Metabolism, 28:946-960.e6 (2018).

2. S. Culina*, A.I. Lalanne*, G. Afonso, K. Cerosaletti, S. Pinto, G. Sebastiani, K. Kuranda, L. Nigi, A. Eugster, T. Østerbye, A. Maugein, J.E. McLaren, K. Ladell, E. Larger, J.P. Beressi, A. Lissina, V. Appay, H.W. Davidson, S. Buus, D.A. Price, M. Kuhn, E. Bonifacio, M. Battaglia, S. Caillat-Zucman, F. Dotta, R. Scharfmann, B. Kyewski, R. Mallone, the ImMaDiab Study Group. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology, 3:eaao4013 (2018).

3: Besançon A, Goncalves T, Valette F, Dahllöf MS, Mandrup-Poulsen T, Chatenoud L, You S. Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice. Diabetologia, 61(2):389-398 (2018).

4: Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife, 5:e08133 (2016).

5. S. Culina, N. Gupta, R. Boisgard, G. Afonso, M.C. Gagnerault, J. Dimitrov, T. Østerbye, S. Justesen, S. Luce, M. Attias, B. Kyewski, S. Buus, F.S. Wong, S. Lacroix-Desmazes, R. Mallone. Materno-fetal transfer of preproinsulin through the neonatal Fc receptor protects from autoimmune diabetes. Diabetes, 64:3532-3542 (2015).