DARCHEN François : UMR 8250 : Synaptic trafficking

Unit : Laboratoire de Neurophotonique CNRS UMR 8250 Université Paris Descartes

Faculté des Sciences Fondamentales et Biomédicales
Université Paris Descartes
Laboratoire de Neurophotonique CNRS UMR 8250
45 rue des Saints-Pères
75270 PARIS Cedex 06

Speciality : Department DGNRV

Director of the unit : Valentina EMILIANI

Principal investigator :

DARCHEN François
Email : francois.darchenSPAMFILTER@parisdescartes.fr Phone number: +33 (0)1 70 64 99 16

Composition of research team :

  • DARCHEN François (DR INSERM, HDR)
  • DESNOS Claire (CR CNRS, HDR)
  • CARREL Damien (MFC)

5 Recent publications of the research team :

Bretou, M., O. Jouannot, I. Fanget, P. Pierobon, N. Larochette, P. Gestraud, M. Guillon, V. Emiliani, S. Gasman, C. Desnos, A.M. Lennon-Duménil, and F. Darchen. Cdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension. Mol Biol Cell. in press

Huet, S., I. Fanget, O. Jouannot, P. Meireles, T. Zeiske, N. Larochette, F. Darchen, and C. Desnos. 2012. Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. J. Neurosci. 32:2564-2577.

Yuseff, M.I., A. Reversat, D. Lankar, J. Diaz, I. Fanget, P. Pierobon, V. Randrian, N. Larochette, F. Vascotto, C. Desdouets, B. Jauffred, Y. Bellaiche, S. Gasman, F. Darchen, C. Desnos, and A.M. Lennon-Dumenil. 2011. Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation. Immunity. 35:361-74.

Bretou, M., C. Anne, and F. Darchen. 2008. A fast mode of membrane fusion dependent on tight SNARE zippering. J Neurosci. 28:8470-6.

Desnos, C., S. Huet, I. Fanget, C. Chapuis, C. Böttiger, V. Racine, J.-B. Sibarita, J.P. Henry, and F. Darchen. 2007. Myosin Va Mediates Docking of Secretory Granules at the Plasma Membrane. J. Neurosci. 27:10636-10645.