MOUILLET-RICHARD Sophie : UMR_S1124 : Signalling and neurological pathophysiology

Unit : INSERM UMR_S1124 - Université Paris Descartes

Faculté des Sciences Fondamentales et Biomédicales
INSERM UMR_S1124 Toxicologie, Pharmacologie et Signalisation cellulaire
45 rue des Saints Pères
75270 Paris cedex 06

Speciality : Department DGNRV

Director of the unit : Robert BAROUKI

Principal investigator :

MOUILLET-RICHARD Sophie
Email : sophie.mouillet-richardSPAMFILTER@parisdescartes.fr Phone number: +33 (0)1 42 86 42 40

Composition of the research team :

  • MOUILLET-RICHARD Sophie (IPEF, détachée CR1-INSERM, HDR)

5 Recent publications of the research team :

HALLIEZ S., Martin-Lannerée S, Passet B, Hernandez-Rapp J, CASTILLE J., URIEN C., CHAT S., LAUDE H., Vilotte JL, Mouillet-Richard S & Beringue V (2015): Prion protein localizes at the ciliary base during neural and cardiovascular development and its depletion affects a-tubulin post-translational modifications Sci Rep (sous presse).

HERNANDEZ-RAPP J.*, Martin-lanneree S.*, Hirsch T.Z.*, PRADINES E., alleaume-butaux a., SCHNEIDER B., BAUDRY A., LAUNAY J.M. & MOUILLET-RICHARD S. (2014): A PrPC-caveolin-Lyn complex negatively controls neuronal GSK3ß and serotonin 1B receptor. Sci Rep 4, 4881. (*: co-premiers auteurs) 

PIETRI M., DAKOWSKI C., Hannaoui s., alleaume-butaux a., HERNANDEZ-RAPP J., Ragagnin A., MouIllet-Richard S., HAIK S., bailly y., peyrin, J.M., Launay J.M., Kellermann O. & SCHNEIDER B. (2013): PDK1 decreases TACE-mediated alpha-secretase activity and promotes disease progression in prion and Alzheimer’s diseases. Nature Med. 19: 1124-1131.

Pradines E.*, HERNANDEZ-RAPP J.*, VILLA-DiAz A., DAKOWSKI C., ARDILA-OSORIO H., HAIK S., SCHNEIDER B., Launay J.M., Kellermann O., Torres J.M., & MouIllet-Richard S. (2013) : Pathogenic prions deviate PrPC signaling in neuronal cells and cause imbalances in A-beta clearance. Cell Death and Disease. 4, e456 (*: co-premiers auteurs) 

BAUDRY A., MOUILLET-RICHARD S., SCHNEIDER B., Launay J-M. & Kellermann O. (2010): MiR-16 targets the serotonin transporter: a new facet for adaptative responses to antidepressant, Science, 329,1537-1541.