GAMAIN Benoît : UMR_S1134 : Severe malaria pathogenesis team

Unit : INSERM UMR_S1134 Biologie Intégrée du Globule Rouge

Institut National de Transfusion Sanguine 
INSERM UMR_S1134
6 Rue Alexandre Cabanel
75739 Paris Cedex 15

Speciality : Department IM

Director of the unit : Yves COLIN

Principal investigator :

GAMAIN Benoît
Email : benoit.gamainSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 49 31 47

Composition of research team :

  • GAMAIN Benoït (DR2-CNRS, HDR)
  • DORIN SEMBLAT Dominique (IR2-INSERM)
  • METRAL Sylvain (IR-INTS)   

5 Recent publications of the research team :

Gangnard, S., Badaut, C., Ramboarina, S., Baron, B., Ramdani, T., Gamain, B., Deloron, P., Lewit Bentley, A., and Bentley, G. A. (2013) Structural and immunological correlations between the variable blocks of the VAR2CSA domain DBL6epsilon from two Plasmodium falciparum parasite lines, J Mol Biol 425, 1697-1711.

Srivastava, A., Gangnard, S., Dechavanne, S., Amirat, F., Lewit Bentley, A., Bentley, G. A., and Gamain, B. (2011) Var2CSA Minimal CSA Binding Region Is Located within the N-Terminal Region, PLoS ONE 6, e20270.

Avril, M., Hathaway, M. J., Srivastava, A., Dechavanne, S., Hommel, M., Beeson, J. G., Smith, J. D., and Gamain, B. (2011) Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates, PLoS ONE 6, e16622.

Srivastava, A., Gangnard, S., Round, A., Dechavanne, S., Juillerat, A., Raynal, B., Faure, G., Baron, B., Ramboarina, S., Singh, S. K., Belrhali, H., England, P., Lewit-Bentley, A., Scherf, A., Bentley, G. A., and Gamain, B. (2010) Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA, Proceedings of the National Academy of Sciences of the United States of America 107, 4884-4889.