PIQUE Claudine & MARGOTTIN-GOGUET Florence : UMR_S1016 UMR8104 : Retrovirus/Quiescence and Proliferation

Unit : INSERM UMR_S1016 CNRS8104 Institut Cochin - Université Paris Descartes

Institut Cochin
INSERM UMR_S1016 CNRS8104
22 rue Méchain
75014 PARIS

Speciality : Department IM

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

PIQUE Claudine & MARGOTTIN-GOGUET Florence
Email : claudine.piqueSPAMFILTER@inserm.fr Phone number: +33 (0)1 40 51 66 16

Composition of research team :

  • PIQUE Claudine (DR2-CNRS, HDR)
  • MARGOTTIN-GOGUET Florence (DR2-INSERM, HDR)
  • RAMIREZ Cecilia (CR1-CNRS, HDR)

5 Recent publications of the research team :

Chazal M, Nzounza P, Pique C, Ramirez BC (2014) . Loss of infectivity of HIV-1 particles produced by mobile lymphocytes. PLoS One. 9(10):e109601. doi: 10.1371/journal.pone.0109601. eCollection 2014.

Pène S, Waast L, Bonnet A, Bénit L, Pique C. (2014). A non-SUMOylated tax protein is still functional for NF-κB pathway activation. J Virol. 88(18):10655-61. doi: 10.1128/JVI.01827-14. Epub 2014 Jul 2.

Journo, C., Bonnet, A., Favre-Bonvin, A., Turpin, J., Vinera, J., Côté, E., Chevalier, S.A., Pique, C* and Mahieux, R*. (2013). HTLV-2 Tax mediated NF-kB activation involves a mechanisms independent of Tax conjugation to ubiquitin and SUMO. J Virol. 87(2):1123-36. doi: 10.1128/JVI.01792-12. Epub 2012 Nov 7.

Dragin L, Nguyen LA, Lahouassa H, Sourisce A, Kim B, Ramirez BC, Margottin-Goguet F (2013). Interferon block to HIV-1 transduction in macrophages despite SAMHD1 degradation and high deoxynucleoside triphosphates supply. Retrovirology. Mar 11;10:30.

Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, Bloch N, Maudet C, Bertrand M, Gramberg T, Pancino G, Priet S, Canard B, Laguette N, Benkirane M, Transy C, Landau NR, Kim B, Margottin-Goguet F (2012). SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol. Feb 12;13(3):223-8.