DAVOUST Jean : UMR_S1151 UMR8253 : Regulatory T cell biology and biotherapy application

Unit : INSERMUMR_S1151 CNRS UMR8253 - Institut Necker-Enfants malades (INEM) Université Paris Descartes

INSERM U1151 CNRS UMR 8253 (INEM)
Hôpital Necker-Enfants Malades
Bâtiment Hamburger porte H1
149 rue de Sèvres
75743 PARIS Cedex 15

Speciality : Department IMMUNO

Director of the unit : Xavier NASSIF

Principal investigator :

DAVOUST Jean
Email : jean.davoustSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 49 53 65

Composition of research team :

  • DAVOUST Jean (DR-CNRS, HDR)
  • GROSS David (CR(INSERM , HDR)

5 Recent publications of the research team :

Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D and Pulendran B. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science, 2014 Jan 17;343(6168):313-7

Carpentier M, Chappert P, Kuhn C, Lalfer M, Flament E, Burlen-Defranoux O, Lantz O, Bandeira, A, Malissen, B, Davoust, J, Gross, DA. Extrathymic induction of Foxp3+ regulatory T cells declines with age in a T-cell intrinsic manner. Eur J Immunol. (2013) 43(10):2598-604

Chappert P, Leboeuf M, Rameau P, Lalfer M, Desbois S, Liblau RS, Danos O, Davoust JM, Gross DA. Antigen-specific Treg impair CD8(+) T-cell priming by blocking early T-cell expansion. Eur J Immunol. (2010)  40(2):339-50

Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P. IRAP identifies an endosomal compartment required for MHC class I cross-presentation.Science. (2009) 325(5937):213-7

Chappert P, Leboeuf M, Monteilhet V, Van Wittenberghe L, Danos O, Davoust J. Gross DA. Antigen-driven interactions with dendritic cells and expansion of Foxp3+ regulatory T cells occur in the absence of inflammatory signal. J Immunol. (2008)  180(1):327-34