MENASCHE Philippe et SILVESTRE Jean-Sébastien : UMR_S970 : Regenerative Therapies for Cardiac and Vascular Diseases

Unit : INSERM UMR_S970 Paris-Centre de Recherche Cardiovasculaire (PARCC) - Université Paris Descartes

Paris Centre de Recherche Cardiovasculaire (PARCC)
Equipe "Thérapies régénératives pour les pathologies cardiaques et vasculaires"
Hôpital Européen Georges Pompidou
56 rue Leblanc
75737 PARIS Cedex 15

Co-director email : jean-sebastien.silvestre@inserm.fr

Speciality : Department BCMPP

Director of the unit : Alain TEDGUI

Principal investigator :

MENASCHE Philippe et SILVESTRE Jean-Sébastien
Email : philippe.menascheSPAMFILTER@egp.aphp.fr Phone number: +33 (0)1 56 09 36 22 (P. Menasche) et +33 (0)1 53 98 80 60 (J.S. Silvestre)

Composition of research team :

  • MENASCHE Philippe (PU-PH, HDR)
  • SILVESTRE Jean-Sébastien (DR2-INSERM, HDR) 
  • BEL Alain (PH)
  • DESNOS Michel (PUPH, HDR)    
  • HAGEGE Alain (PUPH, HDR)    
  • LEVY Bernard (PUPH, HDR)

5 Recent publications of the research team :

Zouggari Y, Ait-Oufella H, Bonnin P, Simon T, Sage AP, Guérin G, Vilar J, Caligiuri G, Tsiantoulas D, Laurans L, Dumeau E, Kotti K, Bruneval K, Charo IF, Binder CJ, Danchin N, Tedgui A, Tedder TF, Silvestre JS*/Mallat Z*. B lymphocytes trigger Ccl7-dependent mobilization of monocytes and promote adverse ventricular remodeling after acute myocardial infarction. *equal contribution. Nature Medicine. 2013. Oct;19(10):1273-80

Loinard C, Zouggari Y, Rueda Quero P, Ramkhelawon B, Cochain C, Vilar J, Récalde A, Richard A, Charue D, Duriez M, Mori M, Arenzana-Seisdedos F, Lévy BI, Heymes C, Silvestre JS. CHOP-10 Limits Postnatal Neovascularization Through the Control of eNOS Gene Expression. Circulation. 2012 J;125(8):1014-26.

Rueda P, Richart A, Récalde A, Gasse P, Vilar J, Guérin C, Lortat-Jacob H, Vieira P, Baleux F, Chretien F, Arenzana-Seisdedos F, Silvestre JS. Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions. Circulation. 2012 Oct 9;126(15):1882-95

Bel A, Planat-Benard V, Saito A, Bonnevie L, Bellamy V, Sabbah L, Bellabas L, Brinon V, Vanneaux V, Pradeau P, Peyrard S, Larghero J, Pouly J, Binder P, Garcia S, Shimizu T, Sawa Y, Okano T, Bruneval P, Desnos M, Hagège AA, Casteilla L, Pucéat M, Menasché P. Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells. Circulation. 2010;122(11 Suppl):S118-23.

Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, Binder P, Hagège A, Desnos M, Renaud JF, Menasché P, Pucéat M. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest 2010;120(4):1125-39