MARCELLIN Patrick : UMR_S1149 ERL 8252 : Physiopathology and treatment of viral hepatitis

Unit : INSERM UMR_S1149 CNRS ERL 8252 Centre de Recherche sur l'Inflammation (CRI) Université Paris Diderot

Centre de Recherche sur l'Inflammation (CRI)
Equipe "Physiopathologie et traitement des hépatites virales"
Faculté de Médecine Xavier Bichat
16 rue Henri Huchard
75890 PARIS Cedex 18

Speciality : Department BCMPP

Director of the unit : Renato MONTEIRO

Principal investigator :

MARCELLIN Patrick
Email : patrick.marcellinSPAMFILTER@bjn.aphp.fr Phone number: +33 (0)1 40 87 53 38

Composition of research team :

  • MARCELLIN Patrick (PU-PH, HDR)   
  • ASSELAH Tarik (PU-PH, HDR)
  • BOYER  (PH)
  • CASTELNAU Corinne (PA)
  • GIUILY Nathalie (PA)
  • MOURY Feryel (PA)
  • POUTEAU Michèle (PA)
  • LAPALUS Martine (IR)

5 Recent publications of the research team :

Martinot-Peignoux M, Carvalho-Filho R, Lapalus M, Netto-Cardoso AC, Lada O, Batrla R, Krause F, Asselah T, Marcellin P.Hepatitis B surface antigen serum level is associated with fibrosis severity in treatment-naïve, e antigen-positive patients. J Hepatol. 2013 Jun;58(6):1089-95.

Marcellin P, Cooper C, Balart L, Larrey D, Box T, Yoshida E, Lawitz E, Buggisch P, Ferenci P, Weltman M, Labriola-Tompkins E, Le Pogam S, Nájera I, Thomas D, Hooper G, Shulman NS, Zhang Y, Navarro MT, Lim CY, Brunda M, Terrault NA, Yetzer ES. Randomized controlled trial of danoprevir plus peginterferon alfa-2a and ribavirin in treatment-naïve patients with hepatitis C virus genotype 1 infection. Gastroenterology. 2013  Oct;145(4):790-800.

Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, Washington MK, Germanidis G, Flaherty JF, Schall RA, Bornstein JD, Kitrinos KM, Subramanian GM, McHutchison JG, Heathcote EJ. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013 Feb 9;381(9865):468-75.

Asselah T, De Muynck S, Broët P, Masliah-Planchon J, Blanluet M, Bièche I, Lapalus M, Martinot-Peignoux M, Lada O, Estrabaud E, Zhang Q, El Ray A, Vidaud D, Ripault MP, Boyer N, Bedossa P, Valla D, Vidaud M, Marcellin P. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol 2012;56:527-32.

Lada, O., A. Gervais, M. Branger, G. Peytavin, B. Roquebert, G. Collin, G. Fraqueiro, R. Moucari, L. Leclerc, M. Martinot-Peignoux, S. Matheron, and P. Marcellin, Quasispecies analysis and in vitro susceptibility of HBV strains isolated from HIV-HBV-coinfected patients with delayed response to tenofovir. Antivir Ther 2012. 17(1): p. 61-70.

Marcellin P, Heathcote EJ, Buti M, Gane E, deMan RA, Krastev Z, Germanidis G, Lee SS, Flisiak R, Kaita K, Manns M, Kotzev I, Tchernev K, Buggisch P, Weilert F, Kurdas OO, Shiffman ML, Trinh H,  Washington MK, Sorbel J, Anderson J, Snow-Lampart A, Mondou E,  Quinn J, Rousseau F. Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B, N Engl J Med 2008;359:2442-2455.