RUSTIN Pierre : UMR_S1141 : Physiopathology and Therapy of Mitochondrial diseases

Unit : INSERM UMR_S1141 - Université Paris Diderot

 

Hôpital Robert Debré
INSERM UMR_S1141 Neuroprotection du cerveau en développement
48 Boulevard Sérurier
75019 PARIS

Speciality : Department DGNRV

Director of the unit : Pierre GRESSENS

Principal investigator :

RUSTIN Pierre
Email : pierre.rustinSPAMFILTER@inserm.fr Phone number: +33 (0)1 40 03 19 89

Composition of research team :

  • RUSTIN Pierre (DRCE-CNRS, HDR)
  • SOUSSI-YANICOSTAS Nadia (CR1-CNRS, HDR)
  • YANICOSTAS Constantin (CR1-CNRS)         
  • RAK Malgorzata (CR2-CNRS)
  • BENIT Paule (IR2 INSERM)
  • BENOIST Jean-François (MCU)
  • HUSSON Isabelle (PH)
  • SCHIFF Manuel (PH)
  • BURGLEN Lydie (PH)

5 Recent publications of the research team :

Andjelkovic A, Oliveira MT, Yalgin C, Cannino G, Dhandapani PK, Dufour E, Rustin P, Szibor M and Jacobs HT. Mutations at the diiron centre of Ciona intestinalis alternative oxidase AOX abolish enzymatic activity and prevent rescue of cytochrome oxidase defects in flies. Scientific Reports 2015, 5, 18295

 

Hangen E, Feraud O, Lachkar S, Fimia GM, Lam NV, Zhu C, Godin I, Flamant S, Bénit P, Doti N, Perfettini JL, Bennaceur AL, Ser-Leroux K, Gonin P, Rustin P, Piacentini M, Ruvo M,  Blomgren K, Kroemer G, Modjtahedi N.  Interaction between AIF and MIA40 regulates respiratory chain biogenesis. Molecular Cell 2015, 58, 1001-114

 

Schiff M, Veauville-Merllie A, Tzagoloff A, Ogier de Baulny H, Rak M, Brivet M, Romero N, Rigal P, Rustin P, Vianey-Saban C, Acquaviva-Bourdain C. 2015 Mitochondrial FAD transporter mutations and riboflavin-responsive exercise intolerance. New Engl J Med (in press)

 

Sepulveda-Diaz JE, Alavi Naini SM, Huynh MB, Ouidja MO, Yanicostas C, Chantepie S, Villares J, Lamari F, Jospin E, van Kuppevelt TH, Mensah-Nyagan AG, Raisman-Vozari R, Soussi-Yanicostas N, Papy-Garcia D. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology  Brain. 2015 May;138(Pt 5):1339-54.

 

Wai T, Prieto JG, Baker M, Merkwirth C, Benit P, Rustin P, Ruperez FJ, Barbas C, Ibanez B, Langer T. 2015 Metabolic intervention rescues heart failure caused by unbalanced mitochondrial dynamics. Science (in press)