RANNOU François : UMR_S1124 : Pharmacology, toxicology, and cell signaling in cartilage and intervertebral disc

Unit : INSERM UMR_S1124 "Toxicologie, Pharmacologie et Signalisation Cellulaire" Université Paris Descartes

Faculté des Sciences Fondamentales et Biomédicales
INSERM UMR_S1124 Toxicologie, Pharmacologie et signalisation cellulaire
45 rue des Saints Pères
75270 Paris cedex 06

Speciality : Department DGNRV

Director of the unit : Robert BAROUKI

Principal investigator :

RANNOU François
Email : francois.rannouSPAMFILTER@cch.aphp.fr Phone number: +33 (0)1 58 41 25 35

Composition of research team :

  • RANNOU François (PU-PH, HDR)
  • BORDERIE Didier (PU-PH, HDR)
  • CHAUVET Caroline (MCF)
  • CORVOL Maité (DR, Emerite)
  • MORIN Nathalie (MCF)
  • NGUYEN Christelle (CCA)

5 Recent publications of the research team :

C. Chenevier-Gobeaux, C. Simonneau, H. Lemarechal, D. Bonnefont-Rousselot, S. Poiraudeau, F. Rannou, O.G. Ekindjian, P. Anract, D. Borderie. (2013) Effect of hypoxia/reoxygenation on the cytokine-induced production of nitric oxide and superoxide anion in cultured osteoarthritic synoviocytes. Osteoarthritis Cartilage. 21 874-81.

S.G. Ladet, K. Tahiri, A.S. Montembault, A.J. Domard, M.T. Corvol, Multi-membrane chitosan hydrogels as chondrocytic cell bioreactors, Biomaterials 32 (2011) 5354-5364.

J.E. Ombetta, N. Thelier, C.Z. Dong, S. Plocki, L. Tsagris, F. Rannou, F. Massicot, A. Djimde, E. El-Hayek, Y. Shi, F. Heymans, N. Gresh, C. Chauvet. (2010)  Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion, PLoS ONE 5 (2010) e10914.

M. Vareille, F. Rannou, N. Thelier, A.L. Glasser, T. de Sablet, C. Martin, A.P. Gobert (2008)  Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes, J Immunol 180 5720-5726.

M. Benallaoua, M. Francois, F. Batteux, N. Thelier, J.Y. Shyy, C. Fitting, L. Tsagris, J. Boczkowski, J.F. Savouret, M.T. Corvol, S. Poiraudeau, F. Rannou (2007)  Pharmacologic induction of heme oxygenase 1 reduces acute inflammatory arthritis in mice, Arthritis Rheum 56 2585-2594.