CHARBIT Alain & NASSIF Xavier : UMR_S1151 UMR8253 : Pathogenesis of Systemic Infections

Unit : INSERM UMR_S1151- CNRS UMR8253 Institut Necker Enfants Malades (INEM) Université Paris Descartes

INEM INSERM U1151 - CNRS UMR 8253
Université Paris Descartes
Bâtiment Leriche – PORTE 9
14 Rue Maria Helena Vieira Da Silva CS 61431
75993 PARIS CEDEX 14

Speciality : Department IM

Principal investigator : Xavier NASSIF

Director of the unit :

CHARBIT Alain & NASSIF Xavier
Email : alain.charbitSPAMFILTER@inserm.fr Phone number: +33 (0)1 72 60 65 12

Composition of research team :

  • NASSIF Xavier (PU-PH, HDR)
  • CHARBIT Alain (DR1-CNRS, HDR)
  • BAREL Monique (DR2-INSERM, HDR)
  • COUREUIL Mathieu (CR2-INSERM, HDR)
  • JOIN-LAMBERT Olivier (MCU-PH)
  • BILLE Emmanuelle (MCU-PH)
  • LECUYER Hervé (MCU-PH)

5 Recent publications of the research team :

Ramond E, Gesbert G, Rigard M, Dairou J, Dupuis M, Dubail I, Meibom K, Henry T, Barel M, Charbit A. (2014).Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in Francisella phagosomal escape. PLoS Pathogens. 2014. Jan. 10(1):e10003893.

Dieppedale J, Gesbert G, Ramond E, CCHUON C, Dubail I, Dupuis M, GUERRERA C, Charbit A. (2013)  Possible links between stress defense and the tricarboxylic acid cycle in Francisella pathogenesis. Mol. Cell. Proteomics 2013. 12 :2278-2292.

Chamot-Rooke J., G. Mikaty, C.Malosse, M.Soyer, A.Dumont, J. Gault, A.F. Imhaus, P. Martin, M. Trellet, G. Clary, P. Chafey, L. Camoin,  M. Nilges, X. Nassif, G. Duménil. (2011). Posttranslational Modification of Pili upon Cell Contact Triggers N. meningitidis Dissemination.  Science, 2011, 331: 778-782.

Coureuil M., Lécuyer H., Scott M., Boularan C., Enslen H., Soyer M., Mikaty G., Bourdoulous S., Nassif X., Marullo S. (2010) Meningococcus hijacks a beta2-adrenoceptor- beta-arrestin pathway to cross brain microvasculature endothelium. Cell, 2010, 143:1149-60.

Alkhuder K, Meibom KL, Dubail I, Dupuis M, Charbit A. (2009). Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis". PLoS Pathogens, Jan. 5(1):e1000284.

Coureuil M, Mikaty G, Miller F, Lécuyer H, Bernard C, Bourdoulous S, Duménil G, Mège RM, Weksler BB, Romero IA, Couraud PO, Nassif X. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science, 2009, 325, 83-87.