POYART Claire et FOUET Agnès : UMR_S1016 - UMR8104 : Pathogenesis of Streptococcal Infections

Unit : INSERM UMRS_1016 CNRS 8104 Institut Cochin - Université Paris Descartes

Institut Cochin
Equipe «  Pathogénie des Infections à Streptocoques »
22 rue Méchain
75014 Paris

Speciality : Department IM

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

POYART Claire et FOUET Agnès
Email : claire.poyartSPAMFILTER@cch.aphp.fr Phone number: +33 (0)1 58 41 15 60 (C. POYART) / +33 (0)1 40 51 64 50 (A. FOUET)

Composition of research team :

  • POYART Claire (PU-PH, HDR)
  • FOUET Agnès (DR2 CNRS)
  • GUIGNOT Julie (CR1 INSERM, HDR)
  • TAZI Asmaa (MCU-PH)

5 Recent publications of the research team :

Tazi A, Disson O, Bellais S, Bouaboud A, Dmytruk N, Dramsi S, Mistou MY, Khun H, Mechler C, Tardieux I, Trieu-Cuot P, Lecuit M, Poyart C. The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates. J Exp Med. 2010. 207(11):2313-22.

Bellais S, Six A, Fouet A, Longo M, Dmytruk N, Glaser P, Trieu-Cuot P, Poyart C. Capsular switching in group B Streptococcus CC17 hypervirulent clone: a future challenge for polysaccharide vaccine development. J Infect Dis. 2012 Dec 1;206(11):1745-52.

Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I, Spinali S, Perkins T, Lechat P, Dmytruk N, Sauvage E, Ma L, Romi B, Tichit M, Lopez-Sanchez MJ, Descorps-Declere S, Souche E, Buchrieser C, Trieu-Cuot P, Moszer I, Clermont D, Maione D, Bouchier C, McMillan DJ, Parkhill J, Telford JL, Dougan G, Walker MJ; DEVANI Consortium, Holden MT, Poyart C, Glaser P. Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nat Commun. 2014 Aug 4;5:4544

Six A, Bellais S, Bouaboud A, Fouet A, Gabriel C, Tazi A, Dramsi S, Trieu-Cuot P, Poyart C. Srr2, a multifaceted adhesin expressed by ST-17 hypervirulent Group B Streptococcus involved in binding to both fibrinogen and plasminogen. Mol Microbiol. 2015 Sep;97(6):1209-2

Dinis M, Plainvert C, Longo M, Guignot J, Gabriel C, Poyart C, Fouet A. Group A Streptococcus emm3 strains induce early macrophage cell death. Pathog Dis. 2016 Mar;74(2)