LE VAN KIM Caroline : UMR_S1134 : Normal and pathological red cell physiology

Unit : UMR_S1134 Biologie Intégrée du Globule Rouge - Université Paris Diderot

INTS
UMR_S1134 Biologie Intégrée du Globule Rouge
6 rue Alexandre Cabanel
75739 PARIS Cedex 15

Speciality : Department BCMPP

Director of the unit : Yves COLIN ARONOVICZ

Principal investigator :

LE VAN KIM Caroline
Email : caroline.le-van-kimSPAMFILTER@inserm.fr Phone number: +33 (0)1 44 49 30 46

Composition of research team :

  • LE VAN KIM Caroline (Pr, HDR)   
  • COLIN-ARONOVICZ Yves (DR-CNRS, HDR)
  • EL NEMER Wassim (CR-INSERM, HDR) 
  • ELION Jacques (PU-PH, HDR) 
  • PEYRARD Thierry (DR, HDR)
  • AZZOUZI Slim (CR)  
  • FILIPE Anne (MCF)
  • FRANCO Mélanie (MCF)   
  • LAPOUMEROULIE Claudine (CR-INSERM)
  • LOPEZ Claude (CR)
  • BROUSSE Valentine (PH Necker, 10 %)

5 Recent publications of the research team :

Franco M, Collec E, Connes P, van den Akker E, Billette de Villemeur T, Belmatoug N, von Lindern M, Ameziane N, Hermine O, Colin Y, Le Van Kim C, Mignot  C. Abnormal properties of red blood cells suggest a role in the pathophysiology of Gaucher disease. Blood. 2013 Jan 17;121(3):546-55.

De Grandis M, Cambot M, Wautier MP, Cassinat B, Chomienne C, Colin Y, Wautier  JL, Le Van Kim C, El Nemer W. JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway. Blood. 2013 Jan 24;121(4):658-65. doi: 10.1182/blood-2012-07-440487. 

Wautier MP, Héron E, Picot J, Colin Y, Hermine O, Wautier JL. Red blood cell phosphatidylserine exposure is responsible for increased erythrocyte adhesion to  endothelium in central retinal vein occlusion. J Thromb Haemost. 2011 May;9(5):1049-55. doi: 10.1111/j.1538-7836.2011.04251.

Bartolucci P, Chaar V, Picot J, Bachir D, Habibi A, Fauroux C, Galactéros F, Colin Y, Le Van Kim C, El Nemer W. Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation. Blood. 2010 Sep 23;116(12):2152-9. doi: 10.1182/blood-2009-12-257444.

Chaar V, Picot J, Renaud O, Bartolucci P, Nzouakou R, Bachir D, Galactéros F,  Colin Y, Le Van Kim C, El Nemer W. Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle  cell disease. Haematologica. 2010 Nov;95(11):1841-8. doi: 10.3324/haematol.2010.026294.