DUTAR Patrick : UMR_S894 : Neurobiology of Normal and Pathological Aging

Unit : INSERM UMR_S894 - Centre de Psychiatrie et Neurosciences - Université Paris Descartes

Centre de Psychiatrie & Neuroscience
Faculté de Médecine Paris Descartes - site Alésia
2 ter rue d’Alésia
75014 PARIS

Speciality : Department DGNRV

Director of the unit : Jacques EPELBAUM

Principal investigator :

DUTAR Patrick
Email : patrick.dutarSPAMFILTER@inserm.fr Phone number: +33 (0)1 40 78 86 04

Composition of research team :

  • DUTAR Patrick  (DR2-CNRS, HDR )
  • BILLARD Jean-Marie (DR2 CNRS, HDR)
  • POTIER  Brigitte (CR1-CNRS)

5 Recent publications of the research team :

Latour, A., Grintal, B., Champeil-Potokar, G., Hennebelle, M., Lavialle, M., Dutar P., Potier, B., Billard, J-M., Vancassel, S., and Denis, I. “Omega-3 fatty acids deficiency aggravates glutamatergic synapse and astroglial ageing in the rat hippocampal CA1”; Aging Cell, 2013, 12(1): 76-84; DOI: 10.1111/acel.12026.

Haxaire C., Turpin F., Potier B., Kervern M., Sinet P-M., Barbanel G., Mothet J.P., Dutar P. and Billard J-M. “Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation”; Aging Cell, 2012, 11 : 336-344.

Kervern M., Angeli A., Nicole O., Léveillé F., Parent B., Villette V., Buisson A. and Dutar P. “Selective impairement of some forms of synaptic plasticity by oligomeric b-Amyloid peptide: implication of extrasynaptic NMDA receptors”;  Journal of Alzheimer’s Disease, 2012, 32:183-196.

Villette V., Poindessous-Jazat F., Bellessort B., Roullot E., Petterschmitt Y.,  Epelbaum J., Stéphan A and Dutar P. “A new neuronal target for beta-amyloid peptide in the rat hippocampus”;  Neurobiology of Aging, 2012, Jun;33(6):1126.e1-14. Epub 2011 Dec 27.

Villette V., Poindessous-Jazat F., Simon A.P., Léna C., Roullot E., Bellessort B.  Epelbaum J., Dutar P. and Stéphan A. Decreased rhythmic GABAergic septal activity and memory-associated theta oscillations after hippocampal Abeta pathology in the rat”; Journal of Neuroscience, 2010, 30(33): 10991-11003.