BOMSEL Morgane : UMR_S1016 UMR8104 : Mucosal Entry of HIV and Mucosal Immunity

Unit : INSERM UMR_S1016 CNRS UMR8104 - Institut Cochin - Univrsité Paris Descartes

Institut Cochin
22 rue Méchain
75014 PARIS

Speciality : Department IM

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

BOMSEL Morgane
Email : Phone number: +33 (0)1 40 51 65 97

Composition of research team :

  • BOMSEL Morgane (DR-CNRS, HDR)
  • GANOR Yonatan (CR-CNRS, HDR)
  • TUDOR Daniela (IR, HDR)

5 Recent publications of the research team :

Ganor Y, Drillet-Dangeard AS, Lopalco L, Tudor D, Tambussi G, Delongchamps NB, Zerbib M, Bomsel M. (2013). Calcitonin gene-related peptide inhibits Langerhans cell-mediated HIV-1 transmission. J Exp Med. 2013;210(11):2161-70.

Tudor D, Yu H, Maupetit J, Drillet AS, Bouceba T, Schwartz-Cornil I, Lopalco L, Tuffery P, Bomsel M. (2012) Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. Proc Natl Acad Sci U S A. 2012;109(31):12680-5.

Zhou Z, Barry de Longchamps N, Schmitt A, Zerbib M, Vacher-Lavenu MC, Bomsel M, Ganor Y. (2011). HIV-1 efficient entry in inner foreskin is mediated by elevated CCL5/RANTES that recruits T cells and fuels conjugate formation with Langerhans cells. PLoS Pathog. 2011;7(6):e1002100.

Bomsel M, Tudor D, Drillet AS, Alfsen A, Ganor Y, Roger MG, Mouz N, Amacker M, Chalifour A, Diomede L, Devillier G, Cong Z, Wei Q, Gao H, Qin C, Yang GB, Zurbriggen R, Lopalco L, Fleury S. (2011). Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity. 2011;34(2):269-80.

Tudor D, Derrien M, Diomede L, Drillet AS, Houimel M, Moog C, Reynes JM, Lopalco L, Bomsel M.(2009). HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis. Mucosal Immunol. 2009;2(5):412-26.