BRICE Alexis : UMR_S1127 : Molecular basis, physiopathology and treatment of neurodegenerative diseases

Unit : INSERM UMR_S1127 Université Pierre et Marie Curie

Institut du Cerveau et de la Moelle Epinière
INSERM UMR_S1127
Hôpital Pitié-Salpêtrière
Bâtiment de l’ICM
47 boulevard de l’Hôpital
75013 PARIS

Speciality : Department DGNRV

Director of the unit : Alexis BRICE

Principal investigator :

BRICE Alexis
Email : alexis.briceSPAMFILTER@upmc.fr Phone number: +33 (0)1 57 27 46 82

Composition of research team :

  • BRICE Alexis (PU-PH, HDR)
  • DEPIENNE Christel (MCU-PH, HDR)
  • DURR Alexandra (PH, HDR)
  • LE BER Isabelle (PH)
  • LESAGE Suzanne (IR-INSERM)

5 Recent publications of the research team :

Martin, E, Schule, R, Smets, K, Rastetter, A, Boukhris, A, Loureiro, J.L, Gonzalez, M.A, Mundwiller, E, Deconinck, T, Wessner, M, Jornea, L, Caballero Oteyza, A, Durr, A, Martin, J.J, Schols, L, Mhiri, C, Lamari, F, Züchner, S, De Jonghe, P, Kabashi, E, Brice, A, Stevanin, G. (2013). Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia. Am. J. Hum. Genet, 92(2):238-44.

Lesage, S, Le Ber, I, Condroyer, C, Broussolle, E, Gabelle, A, Thobois, S, Pasquier, F, Mondon, K, Dion, P, Rochefort, D, Rouleau, G, Dürr, A, Brice, A, for the French Parkinson’s Disease Genetics (PDG) Study Group. (2013). C9ORF72 repeat expansions are a rare genetic cause of parkinsonism. Brain, 136(2): 385-91.

Depienne, C, Bugiani, M, Dupuits, C, Galanaud, D, Touitou, V, Postma, N, Van Berkel, C, Polder, E, Tollard, E, Darios, F, Brice, A, De Die-Smulders, C.E, Vles, J.S, Vanderver, A, Uziel, G, Yalcinkaya, C, Frints, S.G, Kalscheuer, V.M, Klooster, J, Kamermans, M, Abbink, T.E.M, Wolf, N.I, Sedel, F, Van Der Knaap, M.S. (2013). Brain white matter oedema due to ClC-2 chloride channel defi ciency: an observational analytical study. Lancet Neurol, 12(7):659-68.

Bertolin, G, Traver, S, Ferrando-Miguel, R, Dauphin, A, Waharte, F, Ardila-Osorio, H, Muriel, M-P, Takahashi, H, Lees, A.J, Grenier, K, Kontogiannea, M, Fon, E.A, Bayot, A, Lombès, A, Bulteau, A-L, Brice, A, Corti, O. (2013). Parkin interacts with the TOM machinery to modulate mitochondrial protein import. Autophagy, 9(11) :1-17.

Depienne, C, Bouteiller, D, Meneret, A, Billot, S, Groppa, S, Klebe, S, Brüggemann, N, Bhatia, K, Cincotta, M, Brochard, V, Flamand-Roze, C, Carpentier, W, Meunier, S, Marie, Y, Gaussen, M, Stevanin, G, Wehrle, R, Charbonnier-Beaupel, F, Corvol, J-C, Vidailhet, M, Klein, C, Dusart, I, Brice, A, Roze, E. (2012) RAD51 haploisufficiency causes congenital mirror movements in humans. Am. J. Hum. Genet, 90(2):301-7.