DUPRET Jean-Marie et RODRIGUES-LIMA Fernando : UMR 8251 : Metabolic and toxicological enzymology

Unit : CNRS UMR 8251 Unité de Biologie Fonctionnelle et Adaptative (BFA) Université Paris Diderot

Unité de Biologie Fonctionnelle et Adaptative (BFA)
Equipe "Réponses Moléculaires et Cellulaires aux Xénobiotiques"
Bâtiment Buffon, 3ème étage
4, rue Marie Andrée Lagroua Weill Hallé
75205 Paris cedex 13


Email co-director : fernando.rodrigues-lima@univ-paris-diderot.fr

Speciality : Department BCMPP

Director of the unit : Jean-Marie DUPRET

Principal investigator :

DUPRET Jean-Marie et RODRIGUES-LIMA Fernando
Email : jean-marie.dupretSPAMFILTER@univ-paris-diderot.fr Phone number: +33 (1) 57 27 83 30 (J.M. Dupret) +33 (0)1 57 27 83 32 (F. Rodrigues-Lima)

Composition of research team :

  • DUPRET Jean-Marie (Pr, HDR) 
  • RODRIGUES-LIMA Fernando (Pr, HDR) 
  • BUSI Florent (MCF)

5 Recent publications of the research team :

Ragunathan, N., Dairou, J., Sanfins, E., Busi, F., Noll, C., Janel, N., Dupret, J. M., & Rodrigues-Lima, F. (2010). Cadmium alters the biotransformation of carcinogenic aromatic amines by xenobiotic-metabolizing enzymes arylamine N-acetyltransferases: Molecular, cellular and in vivo Studies. Environ Health Perspect 118, 1685-1691.

Sanfins, E., Dairou, J., Hussain, S., Busi, F., Chaffotte, A. F., Rodrigues-Lima, F., & Dupret, J. M. (2011). Carbon Black Nanoparticles Impair Acetylation of Aromatic Amine Carcinogens through Inactivation of Arylamine N-Acetyltransferase Enzymes. ACS Nano 5, 4504-4511. 

Cocaign, A., Bui, L. C., Silar, P., Chan Ho Tong, L., Busi, F., Lamouri, A., Mougin, C., Rodrigues-Lima, F., Dupret, J. M., & Dairou, J. (2013) Biotransformation of Trichoderma spp. and their tolerance to aromatic amines, a major class of pollutants. Appl Environ Microbiol. 79, 4719-4726.

Kubiak, X., Li de la Sierra-Gallay, I., Chaffotte, A. F., Pluvinage, B., Weber, P., Haouz, A., Dupret, J. M., & Rodrigues-Lima, F. (2013) Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad. J Biol Chem. 288, 22493-22505. 

Bui, L.C., Manaa, A., Xu, X., Duval, R., Busi, F., Dupret, J. M., Rodrigues-Lima, F., & Dairou, J. (2013) Acrolein, an α,β-unsaturated aldehyde, irreversibly inhibits the acetylation of aromatic amine xenobiotics by human arylamine N-acetyltransferase 1. Drug Metab Dispos. 41, 1300-1305