LEON Sébastien : UMR7592 : Membrane trafficking, Ubiquitin ans Signaling

Unit : CNRS UMR7592 Institut Jacques Monod - Université Paris Diderot

Institut Jacques Monod - CNRS UMR7592
Université Paris Diderot
Bâtiment Buffon
15 Rue Hélène Brion
75205 PARIS Cedex 13

Speciality : Department BCMPP

Director of the unit : Giuseppe BALDACCI

Principal investigator :

LEON Sébastien
Email : leon.sebastienSPAMFILTER@ijm.fr Phone number: +33 (0)1 57 27 80 50

Composition of research team :

  • LEON Sébastien (CR1-CNRS, HDR)
  • ALBANESE Véronique (CR1 CNRS)   

5 Recent publications of the research team :

Herrador, A., Livas, D., Soletto, L., Becuwe, M., Leon, S., et Vincent, O. (2015). Casein kinase 1 controls the activation threshold of an alpha-arrestin by multisite phosphorylation of the interdomain hinge. Mol Biol Cell 26, 2128-2138.

Becuwe, M., et Leon, S. (2014). Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5. eLife 3.10.7554/eLife.03307

Becuwe, M., Vieira, N., Lara, D., Gomes-Rezende, J., Soares-Cunha, C., Casal, M., Haguenauer-Tsapis, R., Vincent, O., Paiva, S., et Léon, S. (2012). A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol 196, 247-259.

Becuwe, M., Herrador, A., Haguenauer-Tsapis, R., Vincent, O., et Léon, S. (2012). Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family. Biochem Res Int 2012, 242764. (Review)

Herrador, A., Leon, S., Haguenauer-Tsapis, R., et Vincent, O. (2013). A mechanism for protein monoubiquitination dependent on a trans-acting ubiquitin-binding domain. J Biol Chem 288, 16206-16211.