CRESTANI Bruno : UMR_S1152 : Lung Inflammation and Fibrosis

Unit : INSERM UMR_S1152 "Physiopathologie et Epidémiologie des maladies Respiratoires" Université Paris Diderot

UFR de médecine  Xavier Bichat
INSERM UMR_S1152 "Physiopathologie et Epidémiologie des maladies Respiratoires"
16 rue Henri Huchard
75018 PARIS

Speciality : Department BCMPP

Director of the unit : Marina PETROLANI

Principal investigator :

CRESTANI Bruno
Email : bruno.crestaniSPAMFILTER@bch.aphp.fr Phone number: +33 (0)1 40 25 68 00/86 86

Composition of research team :

  • CRESTANI Bruno (PUPH, HDR)
  • BORENSZTAJN Keren (CR1-INSERM)
  • BORIE Raphael (PH)   
  • BESNARD Valérie (CDD-INSERM)  
  • DEHOUX Monique (PH, HDR)
  • MAILLEUX Arnaud (CR1-INSERM) 
  • MARCHAL Joëlle (IR)
  • MIGNOT Sabine (PH)
  • MORDANT Pierre (PHU) 
  • PLANTIER Laurent (MCU-PH)  
  • QUESNEL Christophe (PH, HDR)

5 Recent publications of the research team :

1: Cigna N, Farrokhi Moshai E, Brayer S, Marchal-Somme J, Wemeau-Stervinou L, Fabre A, Mal H, Leseche G, Dehoux M, Soler P, Crestani B*, Mailleux AA*. The Hedgehog system machinery controls Transforming Growth Factor-β –dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis.  Am J Pathol. 2012 ; Dec;181(6):2126-37

2: Quesnel C, Piednoir P, Gelly J, Nardelli L, Garnier M, Leçon V, Lasocki S, Bouadma L, Philip I, Elbim C, Mentre F, Soler P, Crestani B, Dehoux M. Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury. Crit Care Med. 2012;40(1):21-8.

3: Taille C, Grootenboer-Mignot S, Boursier C, Michel L, Debray MP, Fagart J, Barrientos L, Mailleux A, Cigna N, Tubach F, Marchal-Somme J, Soler P, Chollet-Martin S, Crestani B. Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011 ;183(6):759-66.

4: Bantsimba-Malanda C, Marchal-Sommé J, Goven D, Freynet O, Michel L, Crestani B, Soler P. A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice? Am J Respir Crit Care Med. 2010 ;182(3):385-95.

5: Phin S, Marchand-Adam S, Fabre A, Marchal-Somme J, Bantsimba-Malanda C, Kataoka H, Soler P, Crestani B. Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice. Am J Respir Cell Mol Biol. 2010 ;42(3):286-93.