SIMONS Matias : UMR_S1163 : Laboratory of Epithelial Biology and Disease

Unit : INSERM UMR_S1163 IHU Imagine - Institut des Maladies Génétiques - Université Paris Descartes

IHU magine - Institut des Maladies Génétiques
Bâtiment Imagine
Laboratory of Epithelial Biology and Disease
24 boulevard du Montparnasse
75015 PARIS

Speciality : Department DGNRV

Director of the unit : Alain FISCHER

Principal investigator :

Email : Phone number: +33 (0)1 42 75 43 31

Composition of research team :

  • SIMONS Matias (Lab Director)

5 Recent publications of the research team :

Gleixner E et al: V-ATPase/mTOR signaling regulates Megalin-mediated apical endocytosis, Cell Reports, 2014; 10;8(1):10-9

Petzoldt AG et al : Activation of the proton pump, V-ATPase, triggers epithelial overgrowth and invasion in Drosophila, Dis Model Mech, 2013; 6, 689-700

Hermle T el al : Drosophila ATP6AP2/VhaPRR is a novel planar cell polarity core protein that functions in endosomal trafficking, EMBO J, 2013; 32, 245-259

Hermle T et al : Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. Current Biology, 2010; 20(14):1269-1276

Simons M et al: Electrochemical cues regulate the assembly of the Fz/Dsh complex at the plasma membrane during planar epithelial polarization, Nature Cell Biology, 2009; 11, 286 - 294