BROSCH Roland : Institut Pasteur : Integrated Myobacerial Pathogenomics

Unit : Département Génomes et Génétique

Institut Pasteur
Unité Pathogénomique mycobactérienne intégrée (PMI)
25 rue du Docteur Roux
75015 PARIS

Speciality : Department IM

Director of the unit : Didier MAZEL

Principal investigator :

Email : Phone number: +33 (0)1 45 68 84 46

Composition of research team :

  • BROSCH Roland (Chef de Laboratoire IP, HDR)
  • MAJLESSI Laleh (Chercheur IP, HDR)
  • HONORE Nadine (Ingénieur IP)

5 Recent publications of the research team :

Pawlik, A., Garnier, G., Orgeur, M., Tong, P., Lohan, A., Le Chevalier, F., Sapriel, G., Roux, A.L., Conlon, K., Honore, N., Dillies, M.A., Ma, L., Bouchier, C., Coppee, J.Y., Gaillard, J.L., Gordon, S.V., Loftus, B., Brosch, R., and Herrmann, J.L. (2013) Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus. Mol Microbiol. doi: 10.1111/mmi.12387 [Epub ahead of print].
 Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., Fiette, L., Orgeur, M., Fabre, M., Parmentier, C., Frigui, W., Simeone, R., Boritsch, E.C., Debrie, A.S., Willery, E., Walker, D., Quail, M.A., Ma, L., Bouchier, C., Salvignol, G., Sayes, F, Cascioferro, A., Seemann, T., Barbe, V., Locht, C., Gutierrez, M.C., Leclerc, C., Bentley, S.D., Stinear, T.P., Brisse, S., Medigue, C., Parkhill, J., Cruveiller, S., and Brosch, R. (2013) Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet. 45:172-9 .

Sayes, F., Sun, L., Di Luca, M., Simeone, R., Degaiffier, N., Fiette, L., Esin, S., Brosch, R., Bottai, D., Leclerc, C., and Majlessi, L. (2012) Strong Immunogenicity and Cross-Reactivity of Mycobacterium tuberculosis ESX-5 Type VII Secretion -Encoded PE-PPE Proteins Predicts Vaccine Potential. Cell Host Microbe. 11:352-63.

Simeone, R., Bobard, A., Lippmann, J., Bitter, W., Majlessi, L., Brosch, R., and Enninga, J. (2012) Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death. PLoS Pathog. 8:e1002507.

Bottai, D., Majlessi, L., Simeone, R., Frigui, W., Laurent, C., Lenormand, P., Chen, JM., Rosenkrands, I., Huerre, M., Leclerc, C., Cole, S.T., and Brosch, R. (2011). ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J Infect Dis. 203:1155-64