POSTIC Catherine & ISSAD Tarik : UMR_S1016 UMR8104 : Insulin signaling, Glucose sensing and Glucotoxicity

Unit : INSERM UMR_S1016 CNRS8104 Institut Cochin - Université Paris Descartes

Institut Cochin  INSERM UMR_S1016 CNRS8104
Département Endocrinologie Métabolisme et Diabète
24 rue du Faubourg Saint-Jacques
75014 PARIS

Speciality : Department BCMPP

Director of the unit : Pierre-Olivier COURAUD

Principal investigator : POSTIC Catherine & ISSAD Tarik

POSTIC Catherine & ISSAD Tarik
Email : catherine.posticSPAMFILTER@inserm.fr Phone number: +33 (0)1 53 73 27 07

Composition of research team :

  • POSTIC Catherine (DR-CNRS, HDR  
  • BURNOL Anne-Françoise (DR-CNRS, HDR  
  • ISSAD Tarik (DR-CNRS, HDR)  
  • DENTIN Renaud (CR-INSERM)  
  • GUILMEAU Sandra (MCF)   
  • PAGESY Patrick (CR-INSERM)

5 Recent publications of the research team :

Kanwal S, Fardini Y, Pagesy P, N'tumba-Byn T, Pierre-Eugène C, Masson E, Hampe C, Issad T. O-GlcNAcylation-inducing treatments inhibit estrogen receptor α expression and confer resistance to 4-OH-tamoxifen in human breast cancer-derived MCF-7 cells. PLoS One 11;8(7), 2013.

Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset C, Capeau J, Girard J, Guillou H, Postic C. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest.1;122(6):2176-94, 2012.

Dubuquoy C, Robichon C, Lasnier F, Langlois C, Dugail I, Foufelle F, Girard J, Burnol AF, Postic C, Moldes M. Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes.J Hepatol 55(1):145-53, 2011.

Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest. 1;120(12):4316-31, 2010.

Goenaga D, Hampe C, Carré N, Cailliau K, Browaeys-Poly E, Perdereau D, Holt LJ, Daly RJ, Girard J, Broutin I, Issad T, Burnol AF. Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol.23(7):1043-51, 2009.