SALLENAVE Jean-Michel : UMR_S1152 : Innate immunity and anti-infectious pulmonary defences

Unit : INSERM UMR_S1152 "Physiopathologie et Epidémiologie des Maladies Respiratoires"

UFR de Médecine Xavier Bichat
INSERM UMR_S1152 "Physiopathologie et Epidémiologie des Maladies Respiratoires"
16 rue Henri Huchard
75018 PARIS

Speciality : Department IMMUNO

Director of the unit : Marina PRETOLANI

Principal investigator :

SALLENAVE Jean-Michel
Email : jean-michel.sallenaveSPAMFILTER@inserm.fr Phone number: +33157277802

Composition of research team :

  • SALLENAVEJean-Michel (PR1, ci Ex, HDR)    
  • GARCIA-VERDUGO Ignacio (MCF,HDR)    
  • MONTRAVERS Philippe (PU-PH,HDR)    

5 Recent publications of the research team :

Descamps D, Le Gars M, Balloy V, Barbier D, Maschalidi S, Tohme M, Chignard M, Ramphal R, Manoury B, Sallenave JM.(2012). Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. Proc Natl Acad Sci U S A. 109:1619-24.

Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM. (2013). Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo. Am J Respir Crit Care Med.187:170-9. 2012 Dec 6.

Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.(2012). Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med.4:158ra144.

Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012). Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs. Proc Natl Acad Sci U S A.109:16528-33.

Barbier D, Garcia-Verdugo I, Pothlichet J, Khazen R, Descamps D, Rousseau K, Thornton D, Si-Tahar M, Touqui L, Chignard M, Sallenave JM.(2012). Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-ERK-Sp1 dependent pathway. Am J Respir Cell Mol Biol. 47:149-57

Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.(2011). Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology. 140:1272-8