CHICHE Jean-Daniel : UMR_S1016 UMR8104 : Innate immunity, Toll-like receptors ans variability of inflammatory response

Unit : INSERM UMR_S1016 CNRS8104 - Institut Cochin - Université Paris Descartes

Institut Cochin
Immunité innée, récepteurs Toll et variabilité de la réponse inflammatoire
22 rue Méchain
75014 PARIS

Speciality : Department IMMUNO

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

CHICHE Jean-Daniel
Email : jean-daniel.chicheSPAMFILTER@cch.aphp.fr Phone number: +33 (0)1 58 41 27 39

Composition of research team :

  • CHICHE Jean-Daniel  (PU-PH,HDR)     
  • MIRA Jean-Paul (PU-PH,HDR)         
  • PENE Frédéric (MCU-PH,HDR)       
  • TOUBIANA Julie (MCU-PH)       

5 Recent publications of the research team :

F Pène, D Grimaldi, B Zuber, B Sauneuf, C Rousseau, C El Hachem, C Martin, N Belaïdouni, V Balloy, JP Mira, JD Chiche. Toll-like receptor 2 deficiency increases resistance to Pseudomonas aeruginosa pneumonia in the setting of sepsis-induced immune dysfunction.J Infect Dis 2012; 206: 932-42

Courtine E, Cagnard N, Mazzolini J, Antona M, Pène F, Fitting C, Jacques S, Rousseau C, Niedergang F, Gerondakis S, Chiche JD, Ouaaz F, Mira JP. Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis. Innate Immun 2012; 18(5): 753-63

D Grimaldi, S Louis, F Pène, G Sirgo, C Rousseau, YE Claessens, L Vimeux, A Cariou, JP Mira, A Hosmalin, JD Chiche.Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Med 2011; 37(9): 1438-4

 Toubiana J, Rossi AL, Grimaldi D, Belaidouni N, Chafey P, Clary G, Courtine E, Pène F, Mira JP, Claessens YE, Chiche JD.  IMPDHII inhibits Toll-like receptor 2-mediated activation of NF-kB. J Biol Chem 2011; 286 (26): 23319-33

F Pène, B Zuber, E Courtine, C Rousseau, F Ouaaz, J Toubiana, A Tazi, JP Mira, JD Chiche. Dendritic cells modulate lung response to Pseudomonas aeruginosa in a murine model of sepsis-induced immune dysfunction. J Immunol 2008; 181 (12): 8513-20