CAILLAT-ZUCMAN Sophie : UMR1149 : Innate immune responses in the child : role in infections and graft versus host reaction

Unit : UMR-S1149 CRNS ERL8252 - Centre de Recherche sur l'Inflammation (CRI) Université Paris Diderot

Équipe Caillat-Zucman
INSERM UMR 1149
Bâtiment écran, 4ètage
Hôpital Robert Debré
42 Bd Sérurier
75019 PARIS

Speciality : Department IMMUNO

Director of the unit : Renato MONTEIRO

Principal investigator :

CAILLAT-ZUCMAN Sophie
Email : sophie.caillatSPAMFILTER@inserm.fr Phone number: +33 (0)6 80 70 64 16

Composition of research team :

  • CAILLAT-ZUCMAN Sophie (PUPH,HDR)      
  • DALLE Jean-Hugues (PUPH, HDR) 
  • DE MENTHON Mathilde (PH)
  • HOUDOUIN Véronique (MCUPH)
  • PEUCHMAUR Michel (PUPH, HDR)   
  • SENE Damien (MCUPH, HDR)  
  • STERKERS Ghislaine (PUPH, HDR)

5 Recent publications of the research team :

Tognarelli S, Gayet J, Lambert M, Dupuy S, Cohen P, Guillevin L, de Menthon M, Caillat-Zucman S.(2014). Tissue-specific microvascular endothelial cells show distinct capacity to activate NK cells: implications for the pathophysiology of granulomatosis with polyangiitis.  J. Immunol. in  press

Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sène D, et al. (2013). NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome. Sci Transl Med., 5 (195):195ra96.

Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbé C and Caillat-Zucman S. (2012). Human herpesvirus 8 (HHV8) distinctly shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. Plos Pathogens, 8 (1) : e1002486

de Menthon M, Lambert M, Guiard E, Tognarelli S, Bienvenu B , Karras A, Guillevin L and Caillat-Zucman S. (2011). Excessive IL-15 transpresentation endows NKG2D+ CD4 T cells with innate-like lytic capacity to vascular endothelium in Wegener’s vasculitis. Arthritis&Rheumatism, 63 (7): 2116-26

Sène D, Levasseur F, Abel M, Lambert M, Camous X, Hernandez C, Pène V, Rosenberg AR, Jouvin-Marche E, Marche PN, Cacoub P and Caillat-Zucman S. (2010). Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cytokines. Plos Pathogens, 6 (11) : e1001184