TEDGUI Alain and MALLAT Ziad : UMR_S970 : Innate and Adaptive Immunity in Vascular Diseases

Unit : INSERM UMR_S970 - Paris-Centre de Recherche Cardiovasculaire (PARCC) Université Paris Descartes

Paris Centre de Recherche Cardiovasculaire (PARCC)
Hôpital Européen Georges Pompidou
Equipe "Immunité Innée et Adaptative dans les Pathologies Vasculaires"
56 rue Leblanc
75737 PARIS Cedex 15

courriel du codirecteur : ziad.mallat@inserm.fr

Speciality : Department BCMPP

Director of the unit : Alain TEDGUI

Principal investigator :

TEDGUI Alain and MALLAT Ziad
Email : alain.tedguiSPAMFILTER@inserm.fr Phone number: +33 (0)6 63 35 73 10 (A. Tedgui) and +33 (0)6 48 72 48 40 (Z. Mallat)

Composition of research team :

  • TEDGUI Alain (DR-INSERM, HDR)    
  • MALLAT  Ziad (DR-INSERM, HDR)      
  • AIT-OUFELLA Hafid (MCU-PH, HDR)      
  • BODAERT Jacques (PU-PH, HDR)     
  • DANCHIN Nicolas  (PU-PH, HDR)   
  • MEYER Guy (PU-PH, HDR)     
  • POTTEAUX Stéphane (CR-INSERM)    
  • SANCHEZ Olivier (PU-PH, HDR)     
  • TALEB Soraya  (CR-INSERM)

5 Recent publications of the research team :

Zouggari Y*, Ait-Oufella H*, Bonnin P, Simon T, Dumeau E, Guérin C, Vilar J, Bruneval P, Caligiuri C, Kotti S, Tsiantoulas D, Binder CJ, Charo IF, Danchin N, Tedgui A, Tedder TF, Silvestre JS*, Mallat Z*. B lymphocytes trigger MCP3-dependent mobilization of monocytes and promote adverse ventricular remodelling after acute myocardial infarction. Nat Med. 2013;19(10):1273-1280.

Deroide N, Li X, Lerouet D, Van Vré E, Baker L, Harrison J, Poittevin M, Masters L, Nih L, I, Iwakura Y, Ryffel B, Pocard M, Tedgui A, Kubis N, Mallat Z. Mfge8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury. J Clin Invest. 2013;123(3):1176–1181

Ait-Oufella H, Herbin O, Bouaziz D, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vre E, Esposito B, Vilar J, Sirvent J, van Snick J, Tedgui A, Tedder TF, Mallat Z. B cell Depletion reduces the Development of Atherosclerosis in Mice. J Exp Med. 2010;207:1579-1587.

Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadière C, Rénia L, Johnson J, Thraraux PL, Tedgui A, Mallat Z. TGF- activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest, 2010 ;120(2):422-32.

Taleb S, Romain M, Rhamkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, van Snick J, Yoshimura A, Tedgui A, Mallat Z. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med. 2009;206:2067-2077