DI SANTO James : Institut Pasteur : Innate Immunity Unit (INSERM U668)

Unit : Département Immunologie - Institut Pasteur

Institut Pasteur
Unité d'Immunité Inné
Bâtiment Metchnikoff
25 rue du Dr. Roux
75724 PARIS Cedex 15

Speciality : Department IMMUNO

Director of the unit : Matthew ALBERT

Principal investigator :

DI SANTO James
Email : james.di-santoSPAMFILTER@pasteur.fr Phone number: +33 (0)1 45 68 86 96

Composition of research team :

  • DI SANTO  James  (DRE-INSERM, PR IP, HDR)
  • VOSSHENRICH  Christian  (CR-IP, HDR)

5 Recent publications of the research team :

Serafini, N., Klein Wolterink, R.G.J., Satoh-Takayama, N., Xu, W., Vosshenrich, C.A.J., Hendriks, R.W. and Di Santo, J.P. (2014). GATA-3 drives development of RORgt+ group 3 innate lymphoid cells. Journal of Experimental Medicine 211:199-208.

Klein Wolterink, R.G., Serafini, N., van Nimwegen, M., Vosshenrich, C.A., de Bruijn, M.J., Fonseca Pereira, D., Veiga Fernandes, H., Hendriks, R.W., Di Santo, J.P. Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proceedings of the National Academy of Sciences (USA) 110:10240-10245.

García-Ojeda, M.E., Klein Wolterink, R.G., Lemaître, F., Richard-Le Goff, O., Hasan, M., Hendriks, R.W., Cumano, A., Di Santo, J.P.  Gata-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice. (2013) Blood 121:1749-1759.

Huntington, N.D., Alves, N.L., Legrand, N., Lim, A.M., Strick-Marchand, H., Mention, J.-J., Plet, A., Weijer, K., Jacques, Y., Becker, P.D., Guzman, C.A., Soussan, P., Kremsdorf, D., Spits, H. and Di Santo, J.P. (2011) IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proceedings of the National Academy of Sciences (USA) 108:6217-22.

Spits, H. and Di Santo, J.P. (2011) The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nature Immunology 12:21-27.