LEHUEN Agnès : UMR_S1016 UMR8104 : Immunology of Diabetes

Unit : INSERM UMRS_1016 CNRS UMR8104 - Institut Cochin Université Paris Descartes

Institut Cochin
Equipe "Immunology of Diabetes"
Bâtiment  Cassini
123, Boulevard de Port Royal
75014 PARIS

Co-director email : : roberto.mallone@inserm.fr

Speciality : Department IMMUNO

Director of the unit : Pierre-Olivier COURAUD

Principal investigator :

LEHUEN Agnès
Email : agnes.lehuenSPAMFILTER@inserm.fr Phone number: +33 (0)1 43 21 73 84 (A. Lehuen)

Composition of research team :

  • LEHUEN Agnès (DR1 CNRS, HDR) 
  • BOITARD Christian (PUPH, HDR) 
  • LARGER Etienne (PUPH, HDR) 
  • LEMONNIER François (DRE INSERM, HDR) 
  • ROGNER Ute (CR1-CNRS, HDR)

5 Recent publications of the research team :

Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Østerbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R. (2015 Oct). Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes. Diabetes 64(10):3532-42.

Magalhaes I, Pingris K, Poitou C, Bessoles S, Venteclef N, Kiaf B, Beaudoin L, Da Silva J, Allatif O, Rossjohn J, Kjer-Nielsen L, McCluskey J, Ledoux S, Genser L, Torcivia A, Soudais C, Lantz O, Boitard C, Aron-Wisnewsky J, Larger E, Clément K, Lehuen A. (2015 Apr). Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J Clin Invest 125(4):1752-62.

Diana J, Simoni Y, Furio L, Beaudoin L, Agerberth B, Barrat F, Lehuen A. (2013 Jan). Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes. Nat Med. 19(1):65-73.

Scotto M, Afonso G, Østerbye T, Larger E, Luce S, Raverdy C, Novelli G, Bruno G, Gonfroy-Leymarie C, Launay O, Lemonnier FA, Buus S, Carel JC, Boitard C, Mallone R. (2012 Oct) HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes. Diabetes. 61(10):2546-55.

Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C (2011 Dec). Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes. Diabetes. 60(12):3289-99.