DEMANGEL Caroline : Institut Pasteur : Immunobiology of Infection (CNRS URA1961)

Unit : Département d'Immunologie - Institut Pasteur

Institut Pasteur
Unité  Immunobiologie de l’Infection (CNRS URA1961)
25-28 rue du Docteur Roux
75015 PARIS

Speciality : Department IMMUNO

Director of the unit : Gérard EBERL

Principal investigator :

DEMANGEL Caroline
Email : caroline.demangelSPAMFILTER@pasteur.fr Phone number: +33 (0)1 40 61 30 66

Composition of research team :

  • DEMANGEL Caroline (DR-IP, HDR)
  • GUENIN-MACE Laure (CR-IP)

5 Recent publications of the research team :

Guenin-Macé L, Baron L, Chany AC, Tresse C, Saint-Auret S, Jönsson F, Le Chevalier F, Bruhns P, Bismuth G, Hidalgo-Lucas S, Bisson JF, Blanchard N, DEMANGEL C (2015) Shaping mycolactone for therapeutic use against inflammatory disorders. Sci Transl Med, 27;7(289):289ra85.

Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, DEMANGEL C (2014) Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease. PLoS Negl Trop Dis, 10;8(4):e2786.

Guenin-Macé L, Veyron-Churlet R, Thoulouze MI, Romet-Lemonne G, Hong H, Leadlay PF, Danckaert A, Ruf MT, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier MF, DEMANGEL C. (2013) Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest, 123(4):1501-12.

Biot C, Rentsch CA, Gsponer JR, Birkhäuser FD, Jusforgues-Saklani H, Lemaître F, Auriau C, Bachmann A, Bousso P, DEMANGEL C, Peduto L, Thalmann GN, Albert ML. (2012) Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer. Sci Transl Med, 4(137):137ra72.

Guenin-Macé L, Carrette F, Asperti-Boursin F, Le Bon A, Caleechurn L, Di Bartolo V, Fontanet A, Bismuth G, DEMANGEL C (2011) Mycolactone impairs T cell homing by suppressing miRNA control of L-Selectin expression. Proc Natl Acad Sci U S A, 108(31):12833-8.