MOUQUET Hugo : Humoral response to pathogens - Institut Pasteur : Humoral response to pathogens - Institut Pasteur

Unit :

Laboratoire Réponse Humorale aux Pathogènes
Département d’Immunologie, INSERM U1222
Institut Pasteur
28, rue du Docteur Roux
75015 Paris

Speciality : Department IMMUNO

Director of the unit : Hugo MOUQUET

Principal investigator :

MOUQUET Hugo
Email : hmouquetSPAMFILTER@pasteur.fr Phone number: Tel. +33 (0)1 40 61 36 12

Composition of research team :

  • MOUQUET Hugo

5 Recent publications of the research team :

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA. Nature. 2013 Nov14;503(7475):277-80.

 

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio PM, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC.
Nature. 2012 Dec 6;492(7427):118-22.

 

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, Pereyra F, Ho DD, Walker BD, Seaman MS, Bjorkman PJ, Chait BT, Nussenzweig MC. Science. 2011 Sep 16;333(6049):1633-7.

 

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Nature. 2010 Sep 30;467(7315):591-5.

 

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.
Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Nature. 2009 Apr 2;458(7238):636-40