CASANOVA Jean-Laurent : UMR_S 1163 : Human genetics of infectious diseases : Mendelian predisposition

Unit : INSERM UMR_S1163 - IHU Imagine Institut des Maladies Génétiques - Université Paris Descartes

IHU IMAGINE - Institut des Maladies Génétiques
Bâtiment Imagine
Laboratoire de Génétique Humaine des Maladies Infectieuses
24 boulevard Montparnasse
75015 PARIS

Speciality : Department IMMUNO

Director of the unit : Alain FISCHER

Principal investigator : Jean-Laurent CASANOVA

CASANOVA Jean-Laurent
Email : jean-laurent.casanovaSPAMFILTER@inserm.fr Phone number: +33 (0)1 42 75 43 15

Composition of research team :

  • CASANOVA Jean-Laurent (PU-PH, HDR)           
  • JOUANGUY Emmanuelle (DR2 INSERM, HDR)          
  • ZHANG Shen-Ying (CR1 INSERM)
  • PUEL Anne (DR2 INSERM, HDR)
  • LANTERNIER Fanny (MCU-PH)
  • PICARD, Capucine (PU-PH,HDR)                     
  • BUSTAMANTE Jacinta (MCU-PH, HDR)               
  • VOGT Guillaume (CR2 INSERM, HDR)

5 Recent publications of the research team :

Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis SR, Abhyankar A, Itan Y, Patin E, Brebner S, Sackstein P, Puel A, Picard C, Abel L, Quintana-Murci L, Faust SN, Williams AP, Baretto R, Duddridge M, Kini U, Pollard AJ, Gaud C, Frange P, Orbach D, Emile JF, Stephan JL, Sorensen R, Plebani A, Hammarstrom L, Conley ME, Selleri L, Casanova JL. Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science. 2013 May 24;340(6135):976-8

Lanternier F, Pathan S, Vincent QB, Liu L, Cypowyj S, Prando C, Migaud M, Taibi L, Ammar-Khodja A, Boudghene Stambouli O, Guellil B, Jacobs F, Goffard JC, Schepers K, del Marmol V, Boussofara L, Denguezli M, Larif M, Bachelez H, Michel L, Lefranc G, Hay R, Jouvion G, Chretien F, Fraitag S, Bougnoux ME, Boudia M, Abel L, Lortholary O, Casanova JL, Picard C, Grimbacher B, Puel A. Deep dermatophytosis and inherited CARD9 deficiency. N Engl J Med. 2013 Oct 31;369(18):1704-1714.

Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL. Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science. 2012 Sep 28;337(6102):1684-8.

 Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israël L, Trevejo-Nunez G, Bogunovic D, Cepika AM, Macduff D, Chrabieh M, Hubeau M, Bajolle F, Debré M, Mazzolari E, Vairo D, Agou F, Virgin HW, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet JC, Pascual V, Chaussabel D, Notarangelo LD, Puel A, Israël A, Casanova JL, Picard C. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol. 2012 Dec;13(12):1178-86.

Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, Picard C, Trouillet C, Eidenschenk C, Aoufouchi S, Alcais A, Smith O, Geissmann F, Feighery C, Abel L, Smogorzewska A, Stillman B, Vivier E, Casanova JL, Jouanguy E. Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest. 2012 Mar 1;122(3):821-832.