BOURGERON Thomas : Institut Pasteur : Human genetics and cognitive functions

Unit : Département Neurosciences - Institut Pasteur

Institut Pasteur
Unité Génétique humaine et fonctions cognitives
25 rue du Docteur Roux
75015 PARIS

Speciality : Department DGNRV

Director of the unit : BOURGERON Thomas

Principal investigator :

BOURGERON Thomas
Email : thomas.bourgeronSPAMFILTER@pasteur.fr Phone number: +33 (0)1 40 61 32 16

Composition of research team :

  • BOURGERON Thomas (PU, CL, HDR)
  • BURATTI Julien (Ingénieur Bioinformaticien)
  • CLOEZ-TAYARANI Isabelle (CR-IP, HDR)
  • DELORME Richard (PU-PH, HDR)
  • EY Elodie (CR-IP)
  • GOUBRAN-BOTROS Hany (Ingénieur IP)
  • TORO-OLMEDO Roberto (CR-IP)
  • MATHIEU Alexandre (Ingénieur Bioinformaticien IP)

 

5 Recent publications of the research team :

Delorme R, Ey E, Toro R, Leboyer M, Gillberg C, and Bourgeron T. (2013) Progress towards treatments for synaptic defects in autism. Nature Medicine 19:685-94.

Schmeisser MJ, Ey E, Kuebler A, Bockmann J, Wegener S, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED and Boeckers TM. (2012) Hyperactivity and autisticlike behaviours in mice lacking ProSAP1/Shank2. Nature 486 : 256-60.

Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C, Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsäter H, Nygren G, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemière N, Skuse D, Poot M, Holt R, Monaco AP, Järvelä I, Kantojärvi K, Vanhala R, Curran S, Collier DA, Bolton P, Chiocchetti A, Klauck SM, Poustka F, Freitag CM, Waltes R, Kopp M, Duketis E, Bacchelli E, Minopoli F, Ruta L, Battaglia A, Mazzone L, Maestrini E, Sequeira AF, Oliveira B, Vicente A, Oliveira G, Pinto D, Scherer SW, Zelenika D, Delepine M, Lathrop M, Bonneau D, Guinchat V, Devillard F, Assouline B, Mouren MC, Leboyer M, Gillberg

C, Boeckers TM, Bourgeron T. (2012) Genetic and functional analyses of SHANK2 mutations provide evidence for a multiple hit model of autism spectrum disorders. PLoS Genetics 8(2):e1002521.

Durand C, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, Nygren G, Rastam M, Gillberg IC, Anckarsäter H, Sponheim E, Goubran-Botros H, Delorme R, Chabane N, Mouren- Simeoni MC, de Mas P, Bieth E, Rogé B, Héron D, Burglen L, Gillberg C, Leboyer M, Bourgeron T ;(2007) Mutations of the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics 39:25-7.

Jamain S, Quach H, Betancur C, Råstam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, and Bourgeron T (2003). Mutations of the X-linked neuroligins NLGN3 and NLGN4 are associated with autism Nature Genetics 34, 27-29.