CAVAZZANA Marina & ANDRE-SCHMUTZ Isabelle : UMR_S1163 : Human Lymphohematopoiesis Laboratory

Unit : INSERM UMR_S1163 IHU Imagine - Institut des Maladies génétiques - Université Paris Descartes

IHU Imagine Institut des Maladies Génétiques
Bâtiment Imagine
Laboratoire de Lympho-Hématopoïèse Humaine
24 boulevard du Montparnasse
75015 PARIS

mail du codirecteur : isabelle.andre-schmutz@inserm.fr

Speciality : Department BCMPP

Director of the unit : Alain FISCHER

Principal investigator :

CAVAZZANA Marina & ANDRE-SCHMUTZ Isabelle
Email : m.cavazzanaSPAMFILTER@nck.aphp.fr Phone number: +33 (0)1 44 49 50 68 (M. Cavazzana) +33 (0)1 42 75 43 37 (I. Andre-Schmutz)

Composition of research team :

  • CAVAZZANA Marina  (PU-PH, HDR) 
  • ANDRE-SCHMUTZ Isabelle (DR2-INSERM, HDR)    
  • DURANDY Anne (DRCE-INSERM Eméritat)   
  • KRACKER Sven (CR1-CNRS)
  • SIX Emmanuelle (CR1-INSERM)      
  • TOUZOT Fabien (PH)      
  • LAGRESLE-PEYROU Chantal (IR-INSERM)    
  • DE CHAPPEDELAINE Corinne (IR Faculté)

5 Recent publications of the research team :

Glauzy S, André-Schmutz I, Larghero J, Ezine S, Peffault de Latour R, Moins-Teisserenc H, Servais S, Robin M, Socié G, Clave E, Toubert A. (2014). CXCR4-related increase of circulating human lymphoid progenitors after allogeneic hematopoietic stem cell transplantation. PLOSone  (accepted).

Reimann C, Six E, Dal-Cortivo L, Schiavo A, Appourchaux K, Lagresle-Peyrou C, de Chappedelaine C, Ternaux B, Coulombel L, Beldjord K, Cavazzana-Calvo M, André-Schmutz I. (2012) .  Human T-lymphoid Progenitors Generated in a Feeder-cell-free DL- 4 Culture System Promote T-cell Reconstitution in NOD/SCID/γc(-/-) Mice. Stem Cells. 30 : 1771-80

Kracker S, Durandy A. (2011). Connection between induction of DNA lesions and DNA recombination/repair during Ig class switch recombination. Cell Cycle. 10 :1335-6.

Cavazzana-Calvo M*, Payen E*, Negre O, Wang G, Hehir K, Fusil F, Down J, Denaro M, Brady T, Westerman KA, Cavallesco R, Gillet-Legrand B, Caccavelli L, Sgarra R, Maouche-Chrétien L, Bernaudin F, Girot R, Dorazio R, Mulder GJ, Polak A, Bank A, Soulier J, Larghero J, Kabbara N, Dalle B, Gourmel B, Socie G, Chretien S, Cartier N, Aubourg P, Fischer A, Cornetta K, Galacteros F, Beuzard Y, Gluckman E, Bushman F, Hacein-Bey-Abina S*, Leboulch P*. (2010). (* These authors contributed equally to this work). Transfusion independence and HMGA2 activation after gene therapy of human b-thalassaemia. Nature ;467:318-22

Ditadi A, De Coppi P, Picone O, Gautreau L, Smati R, Six EM, Bonhomme D, Ezine S, Frydman R, Cavazzana-Calvo M*, André-Schmutz I* (2009). (* These authors contribued equally to this work). Human and murine amniotic fluid c-Kit+Lin- cells display hematopoietic activity. Blood ; 113:3953-60.

Lagresle-Peyrou C*, Six EM*, Picard C, Rieux-Laucat F, Michel V, DITADI A, Demerens-de Chappedelaine C, Morillon E, Valensi F, Simon-Stoos KL, Mullikin JC, Noroski LM, Besse C, Wulffraat NM, Ferster A, Abecasis MM, Calvo F, Petit C, Candotti F, Abel L, Fischer A, Cavazzana-Calvo M. (2009). Human adenylate kinase 2 deficiency causes a profound haematopoietic defect. Nat Genet ; 41:106-11( *These authors contributed equally to this work).