ROSENBERG Arielle : EA4474 : Hepatitis C Virology

Unit : EA 4474 "Virologie de l'Hépatite C" Institut Cochin (INSERM UMR_S1016 CNRS 8104) Université Paris Descartes

Institut Cochin
EA 4474 "Virologie de l'Hépatite C"
22 rue Méchain
75014 PARIS

Speciality : Department BCMPP

Director of the unit : Arielle ROSENBERG

Principal investigator :

ROSENBERG Arielle
Email : arielle.rosenbergSPAMFILTER@parisdescartes.fr Phone number: +33 (0)1 40 51 64 93

Composition of research team :

  • ROSENBERG Arielle  (MCU-PH1, HDR)
  • BENHAMOU Yves (PH)         
  • MERITET Jean-François (PH)
  • PODEVIN Philippe (PH, HDR)

5 Recent publications of the research team :

Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology 2012;143:213-22.

Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV Jr, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat. Med. 2010;16:1295-8.

Podevin P°, Carpentier A°, Pène V, Aoudjehane L, Carrière M, Zaïdi S, Hernandez C, Calle V, Méritet JF, Scatton O, Dreux M, Cosset FL, Wakita T, Bartenschlager R, Demignot S, Conti F, Calmus Y*, Rosenberg AR* (° or * equal contribution). Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes. Gastroenterology 2010;139:1355-64. (Accompanying editorial by Lindenbach BD.)

Pène V, Hernandez C, Vauloup-Fellous C, Garaud-Aunis J, Rosenberg AR. Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment. J. Viral Hepat. 2009;16:705-15.

Vauloup-Fellous C, Pène V, Garaud-Aunis J, Harper F, Bardin S, Suire Y, Pichard E, Schmitt A, Sogni P, Pierron G, Briand P, Rosenberg AR. Signal peptide peptidase-catalyzed cleavage of hepatitis C virus core protein is dispensable for virus budding but destabilizes the viral capsid. J. Biol. Chem. 2006;281:27579-92.