HUGOT Jean-Pierre et OGIER-DENIS Eric : UMR_S1149 ERL 8252 : Gut Inflammation

Unit : INSERM UMR_S1149 CNRS ERL 8252 Centre de Recherche sur l'Inflammation (CRI) Université Paris Diderot

Centre de Recherche sur l'Inflammation (CRI)
UFR de Médecine Xavier Bichat
16 rue Henri Huchard
75890 PARIS Cedex 18

courriel du co-directeur : eric.ogier-denis@inserm.fr

Speciality : Department BCMPP

Director of the unit : Renato MONTEIRO

Principal investigator :

HUGOT Jean-Pierre et OGIER-DENIS Eric
Email : jean-pierre.hugotSPAMFILTER@rdb.aphp.fr Phone number: +33 (0)1 40 03 57 12 (J.P. Hugot) +33 (0)1 57 27 73 07 (E. Ogier-Denis)

Composition of research team :

  • HUGOT Jean-Pierre  (PUPH, HDR)     
  • OGIER-DENIS Eric (DR, HDR)  
  • BARREAU Frédérick  (CR, HDR) 
  • BOUHNIK Yoram (PUPH, HDR)  
  • CAZALS-HATEM Dominique (PH) 
  • DANIEL Fanny (CR, HDR)    
  • DUMAY Anne  (MCF)
  • PANIS Yves (PUPH, HDR)      
  • PEDRUZZI Eric (IR)
  • TRETON Xavier (MCU-PH)

5 Recent publications of the research team :

Jung C, Meinzer U, Montcuquet N, Thachil E, Château D, Thiébaut R, Roy M, Alnabhani Z, Berrebi D, Dussaillant M, Pedruzzi E, Thenet S, Cerf-Bensussan N, Hugot JP, Barreau F. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J Clin Invest. 2012 ; 122: 2239-51 (IF 14.1).

Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Léger T, Ben-Mkaddem S, Berrebi D, Dussaillant M, Alnabhani Z, Roy M, Bonacorsi S, Wolf-Watz H, Perroy J, Ollendorff V, Hugot JP. Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe. 2012 ; 11: 337-51 (IF 13.7).

Thachil E, Hugot JP, Arbeille B, Paris R, Grodet A, Peuchmaur M, Codogno P, Barreau F, Ogier-Denis E, Berrebi D, Viala J. Abnormal activation of autophagy-induced crinophagy in Paneth cells from patients with Crohn's disease. Gastroenterology. 2012;142: 1097-1099 (IF 12).

Tréton X, Pédruzzi E, Cazals-Hatem D, Grodet A, Panis Y, Groyer A, Moreau R, Bouhnik Y, Daniel F, Ogier-Denis E. Altered endoplasmic reticulum stress affects translation in inactive colon tissue from patients with ulcerative colitis. Gastroenterology 2011;141:1024-35 (IF=12.032)

Barreau F, Madre C, Meinzer U, Berrebi D, Dussaillant M, Merlin F, Eckmann L, Karin M, Sterkers G, Bonacorsi S, Lesuffleur T, Hugot JP. Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches. Gut. 2010; 59: 207-17 (IF 10.6).