ARBIBE Laurence : UMR_S1151 UMR8253 : Genomic plasticity and infection

Unit : INSERM UMR_S1151 - CNRS UMR8253 Institut Necker Enfants Malades (INEM) Université Paris Descartes

Université Paris Descartes
Bâtiment Leriche - Porte 9
14 rue Maria Helena Vieira Da Silva CS 61431
75993 PARIS Cedex 14

Speciality : Department IM

Director of the unit : Xavier NASSIF

Principal investigator :

ARBIBE Laurence
Email : Phone number: +33 (0)1 72 60 64 30

Composition of research team :

  • ARBIBE Laurence (DR2-INSERM, HDR)

5 Recent publications of the research team :

1-Habiba Harouz, Christophe Rachez, Benoit M. Meijer, Benoit Marteyn, Françoise Donnadieu , Florence Cammas, Christian Muchardt, Philippe Sansonetti and Laurence Arbibe. Shigella flexneri targets the HP1g subcode through the phosphothreonine lyase OspF. EMBO J 2014, 12 , 120-137

2- Jean Bergounioux, Ruben Elisee, Anne-Laure Prunier, Françoise Donnadieu, Brice Sperandio, Philippe Sansonetti and Laurence Arbibe . Calpain Activation by the Shigella flexneri Effector VirA Regulates Key Steps in the Formation and Life of the Bacterium’s Epithelial Niche. Cell Host Microbe 2012 11, 240–252

3- Arbibe L, Kim DW, Batsche E, Pedron T, Mateescu B, Muchardt C, Parsot C, Sansonetti PJ.
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol 2007;8:47-56.

4- Arbibe, L., Mira, J.P., Teusch, N., Kline, L., Guha, M., Mackman, N., Godowski, P.J., Ulevitch, R., and U. Knaus. Toll-like receptor 2-mediated Nf-kB activation requires a Rac1-dependent pathway.
Nat Immunol, 2000, 6 : 533-540.

5- Arbibe, l., Koumanov, k,, Vial, D., Rougeot, C., Faure, G., Havet, N., Longacre, S., Vargaftig, B., Béréziat, G., Voelker, D.R., Wolf, C., and L. Touqui. Generation of lysophospholipds from surfactant in Acute lung Injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant proteinA-phospholipase A2 protein interaction. J Clin Invest, 1998, 6 :1152-1160