DE VILLARTAY Jean-Pierre et REVY Patrick : UMR_S1163 : Genome dynamics in the immune system

Unit : INSERM UMR_S1163 IHU Imagine - Institut des maladies génétiques - Université Paris Descartes

IHU Imagine - Institut des Maladies Génétiques
Bâtiment Imagine
Equipe "Dynamique du génome et du système immunitaire"
24 boulevard du Montparnasse
75015 PARIS

Speciality : Department DGNRV

Director of the unit : Alain FISCHER

Principal investigator :

DE VILLARTAY Jean-Pierre et REVY Patrick
Email : jean-pierre.de-villartaySPAMFILTER@inserm.fr Phone number: +33 (0)1 44 49 50 81 (DE VILLARTAY) - +33 (0)1 44 49 50 85 (REVY)

Composition of research team :

  • de VILLARTAY Jean-Pierre (DRCE-INSERM, HDR)
  • REVY Patrick (DR2-CNRS, HDR)
  • MOSHOUS Despina (MCU-PH)

5 Recent publications of the research team :

Le Guen T, Touzot F, André-Schmutz I, Callebaut I, Lagresle-Peyrou C, Lambert N, Picard C, Nitschke P, Carpentier W, Fabrega S, Cagnard N, Bole-Feysot C, Lim A, Cavazzana M, Soulier J, Jabado N, Fischer A,  De Villartay JP, Revy P. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation. J Allergy Clin Immunol. 2015. sous presse

Rivera-Munoz P, Abramowski V, Jacquot S, André P, Charrier S, Lipson-Ruffert K, Fischer A, Galy A, Cavazzana M, de Villartay JP. Lymphopoiesis in transgenic mice over-expressing Artemis. Gene Ther. 2015 Oct 1. doi: 10.1038/gt.2015.95.

Le Guen T, Jullien L, Touzot F, Schertzer M, Gaillard L, Perderiset M, Carpentier W, Nitschke P, Picard C, Couillault G, Soulier J, Fischer A, Callebaut I, Jabado N, Londono-Vallejo A, de Villartay JP, Revy P. Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability. Hum Mol Genet. 2013;22(16):3239-49.

Moshous D, Martin E, Carpentier W, Lim A, Callebaut I, Canioni D, Hauck F, Majewski J, Schwartzentruber J, Nitschke P, Sirvent N, Frange P, Picard C, Blanche S, Revy P, Fischer A, Latour S, Jabado N, de Villartay JP. Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation. J Allergy Clin Immunol. 2013;131(6):1594-603

Vera G, Rivera-Munoz P, Abramowski V, Malivert L, Lim A, Bole-Feysot C, Martin C, Florkin B, Latour S, Revy P, de Villartay JP. Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans. Mol Cell Biol. 2013; 33(4):701-11