ZENNARO Maria-Christina : UMR_S970 : Genetics Mechanisms of Aldosterone-Related Disorders

Unit : INSERM UMR_S970 - Paris-Centre de Recherche Cardiovasculaire - Université Paris Descartes

Paris Centre de Recherche Cardiovasculaire (PARCC)
Hôpital Européen Georges Pompidou
56 rue Leblanc
75737 PARIS Cedex 15

Speciality : Department BCMPP

Director of the unit : Alain TEDGUI

Principal investigator :

ZENNARO Maria-Christina
Email : maria-christina.zennaroSPAMFILTER@inserm.fr Phone number: +33 (0)1 53 98 80 42

Composition of research team :

  • ZENNARO Maria-Christina (DR2-INSERM, HDR)
  • BOULKROUN Sheerazed (CR1-INSERM)
  • AMAR Laurence (PHU)
  • MEATCHI Tchao (PH)

5 Recent publications of the research team :

Escoubet B, Couffignal C, Laisy JP, Mangin L, Chillon S, Laouenan C, Serfaty JM, Jeunemaitre X, Mentre F, Zennaro MC. Cardiovascular effects of aldosterone: insight from adult carriers of mineralocorticoid receptor mutations. Circulation. Cardiovascular genetics. 2013;6:381-390.

Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC*, Strom TM*, Reincke M. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45:440-444. *equal contribution

Boulkroun S, Beuschlein F, Rossi GP, Golib-Dzib JF, Fischer E, Amar L, Mulatero P, Samson-Couterie B, Hahner S, Quinkler M, Fallo F, Letizia C, Allolio B, Ceolotto G, Cicala MV, Lang K, Lefebvre H, Lenzini L, Maniero C, Monticone S, Perrocheau M, Pilon C, Plouin PF, Rayes N, Seccia TM, Veglio F, Williams TA, Zinnamosca L, Mantero F, Benecke A, Jeunemaitre X, Reincke M, Zennaro MC. Prevalence, Clinical, and Molecular Correlates of KCNJ5 Mutations in Primary Aldosteronism. Hypertension. 2012;59:592-598.

Hubert EL, Teissier R, Fernandes-Rosa FL, Fay M, Rafestin-Oblin ME, Jeunemaitre X, Metz C, Escoubet B, Zennaro MC. Mineralocorticoid receptor mutations and a severe recessive pseudohypoaldosteronism type 1. J Am Soc Nephrol. 2011;22:1997-2003.

Boulkroun S, Samson-Couterie B, Dzib JF, Lefebvre H, Louiset E, Amar L, Plouin PF, Lalli E, Jeunemaitre X, Benecke A, Meatchi T, Zennaro MC. Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism. Hypertension. 2010;56:885-892.