GRESSENS Pierre : UMR_S1141 : Genetic disorders of the developing brain

Unit : INSERM UMR_S1141 - Université Paris Diderot

INSERM UMR_S1141  Neuroprotection du cerveau en développement
Hôpital Robert Debré
48 Boulevard Sérurier
75019 Paris

Speciality : Department DGNRV

Director of the unit : Pierre GRESSENS

Principal investigator :

Email : Phone number: +33 (0)7 78 64 85 95

Composition of research team :

  • GRESSENS Pierre (DR2, HDR)
  • BENZACKEN Brigitte (PU-PH, HDR)
  • BILLETTE Thierry (PU-PH, HDR)
  • BOUIZAR Zhor (CR1, HDR)
  • BURGLEN Lydie (PH, HDR)
  • CAREL Jean-Claude (PU-PH, HDR)
  • De ROUX Nicolas (MCU-PH, HDR)
  • DELAHAYE Andrée (MCU-PH)
  • EL GHOUZZI Vincent (CR1)
  • GUIMIOT Fabien (MCU-PH)
  • LEBON Sophie (IR)
  • LEGER Juliane (PU-PH, HDR)
  • NARDELLI Jeannette (CR1,HDR)
  • OURY Jean-François (PU-PH, HDR)
  • PASSEMARD Sandrine (MCU-PH)
  • PAULSEN Anne (PH)
  • SIMON Dominique (PH)
  • Van Den ABBEELE Thierry (PU-PH, HDR)
  • VERLOES Alain (PU-PH, HDR)

5 Recent publications of the research team :

Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P*, Lelièvre V*. (2011) VIP blockade disrupts Mcph1-Chck1 signaling leading to microcephaly in mice. J. Clin. Invest., 2011, 121: 3071-3087.

Nicholas AK, Khurshid M, Désir J, Carvalho OP, Cox JJ, Thornton G, Kausar R, Ansar M, Ahmad W, Verloes A, Passemard S, Misson JP, Lindsay S, Gergely F, Dobyns WB, Roberts E, Abramowicz M, Woods CG. (2010) WDR62 is associated with the spindle pole and is mutated in human microcephaly. Nat Genet., 2010, 42 : 1010-1014.

Huijbregts, L. and de Roux, N., (2010) KISS1 is down-regulated by 17beta-estradiol in MDA-MB-231 cells through a nonclassical mechanism and loss of ribonucleic acid polymerase II binding at the proximal promoter. Endocrinology, 2010. 151(8): 3764-72.

Teixeira L, Guimiot F, Dode C, Fallet-Bianco C, Millar Rp, Delezoide A.L., Hardelin J.P. (2010). Defective migration of neuroendocrine GnRH cells in human arhinencephalic conditions. J Clin Invest. Oct; 120(10):3668-72 

Labauge P, Horzinski L, Ayrignac X, Blanc P, Vukusic S, Rodriguez D, Mauguiere F, Peter L, Goizet C, Bouhour F, Denier C, Confavreux C, Obadia M, Blanc F, de Sèze J, Fogli A, Boespflug-Tanguy O. (2009) Natural history of adult-onset eIF2B-related disorders: a multi-centric survey of 16 cases. Brain. 2009, 132(Pt 8):2161-9.