THARAUX Pierre-Louis et CAMERER Eric : UMR_S970 : GPCRs and tyrosine kinase receptors; role and interactions in development and disease

Unit : INSERM UMR_S970 Paris-Centre de Recherche Cardiovasculaire (PARCC) Université Paris Descartes

Paris Centre de Recherche Cardiovasculaire (PARCC)
Hôpital Européen Georges Pompidou
Equipe "GPCRs and tyrosine kinase receptors; role and interactions in development and disease"
56 rue Leblanc
75737 PARIS Cedex 15

courriel du codirecteur : eric.camerer@inserm.fr

Speciality : Department BCMPP

Director of the unit : Alain TEDGUI

Principal investigator :

THARAUX Pierre-Louis et CAMERER Eric
Email : pierre-louis.tharauxSPAMFILTER@inserm.fr Phone number: +33 (0)1 53 98 80 48 (P.L. Tharaux) and +33 (0)6 89 50 29 48 (E. Camerer)

Composition of research team :

  • CAMERER Eric (CR1-INSERM)  Approved, Pending Defense
  • THARAUX Pierre-Louis (DR2-INSERM, HDR)      

5 Recent publications of the research team :

Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011 17:1242-50.   

Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srnivasan Y, Farady CJ, Brown C, Xu SM, Lin CY, Craik CS, Kirhhofer D and Coughlin SR. Local protease signalling contributes to neural tube closure in the mouse embryo. Dev Cell 2010 18:25-38

Casanova D, Bouzigues C, Nguyên TL, Ramodiharilafy RO, Bouzhir-Sima L, Gacoin T, Boilot JP, Tharaux PL, Alexandrou A. Single europium-doped nanoparticles measure temporal pattern of reactive oxygen species production inside cells. Nat Nanotechnol. 2009 4:581-5.

Camerer E, Regard JB, Cornelissen I, Srnivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R and Coughlin SR. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation- induced vascular leak in mice. J Clin Invest 2009 119:1871-9

Sabaa N, de Franceschi L, Bonnin P, Castier Y, Malpeli G, Debbabi H, Galaup A, Maier-Redelsperger M, Vandermeersch S, Scarpa A, Janin A, Levy B, Girot R, Beuzard Y, Leboeuf C, Henri A, Germain S, Dussaule JC, Tharaux PL. Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. J Clin Invest. 2008 118:1924-33.