BEHAR-COHEN Francine : UMR_S872 : From the physiopathology of retinal diseas to clinical developments

Unit : INSERM UMR_S872 Centre de Recherche des Cordeliers Universités Paris Descartes et Pierre et Marie Curie

Centre des Recherches des Cordeliers
Equipe "Physiopathologie des maladies oculaires.. Innovations thérapeutiques"
15, rue de l’Ecole de Médecine
75006 PARIS

Speciality : Department BCMPP

Director of the unit : Hervé FRIDMAN

Principal investigator :

BEHAR-COHEN Francine
Email : francine.beharSPAMFILTER@gmail.com Phone number: + 33 (0)1 44 27 81 63

Composition of research team :

  • BEHAR-COHEN Francine (PU-PH, HDR) 
  • DINET Virginie (CR) 
  • KERMORVANT Elsa (MCU-PH) 
  • KRANTIC Slavica (CR1, HDR)
  • TORRIGLIA Alicia (DR2, HDR)
  • VALLEIX Sophie  (MCU, HDR) 
  • COURTOIS Yves  (Emérite, HDR 
  • JEANNY Jean-Claude (Emérite, HDR) 
  • DEKOZAK Yvonne (Emérite, HDR)  

5 Recent publications of the research team :

Dinet V, Bruban J, Chalour N, Maoui A, An N, Jonet L, Buret A, Behar-Cohen F, Klein C, Treton J, Mascarelli F (Distinct effects of inflammation on gliosis, osmohomeostasis, and vascular integrity during amyloid beta-induced retinal degeneration. Aging Cell 11:683-693.2012).

Omri S, Behar-Cohen F, de Kozak Y, Sennlaub F, Verissimo LM, Jonet L, Savoldelli M, Omri B, Crisanti P (Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKCzeta in the Goto Kakizaki rat model. Am J Pathol 179:942-953.2011)

Valleix S, Gillmore JD, Bridoux F, Mangione PP, Dogan A, Nedelec B, Boimard M, Touchard G, Goujon JM, Lacombe C, Lozeron P, Adams D, Lacroix C, Maisonobe T, Plante-Bordeneuve V, Vrana JA, Theis JD, Giorgetti S, Porcari R, Ricagno S, Bolognesi M, Stoppini M, Delpech M, Pepys MB, Hawkins PN, Bellotti V (Hereditary systemic amyloidosis due to Asp76Asn variant beta2-microglobulin. N Engl J Med 366:2276-2283.2012).

Villalpando Rodriguez GE, Torriglia A (Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2. Biochim Biophys Acta 1833:2244-2253.2013).

Zhao M, Celerier I, Bousquet E, Jeanny JC, Jonet L, Savoldelli M, Offret O, Curan A, Farman N, Jaisser F, Behar-Cohen F (Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy. J Clin Invest 122:2672-2679.2012).