THERY Clotilde : UMR_S932 : Exosomes and Tumor Growth

Unit : INSERM UMR_S932 Immunité et Cancer Institut Curie/Université Paris Descartes

INSERM UMR_S932 Immunité et Cancer
Institut Curie
26 rue d’Ulm
75005 Paris

Speciality : Department BCMPP

Director of the unit : Sebastian AMIGORENA

Principal investigator :

THERY Clotilde
Email : clotilde.therySPAMFILTER@curie.fr Phone number: +33 (0)1 56 24 67 16

Composition of research team :

  • THERY Clotilde (DR2-INSERM)

5 Recent publications of the research team :

M. El-Behi, S. Krumeich, C. Lodillinsky, A. Kamoun, L. Tibaldi, G. Sugano, A. de Reynies, E. Chapeaublanc, A. Laplanche, T. Lebret, Y. Allory, F. Radvanyi, O. Lantz, A.M. Eijan, I. Bernard-Pierrot*, C. Théry*. (2013). An essential role for decorin in bladder cancer invasiveness. EMBO Mol Med : 1835-51.

M. Colombo, C. Moita, G. van Niel, J. Kowal, J. Vigneron, P. Benaroch, N. Manel, L. F. Moita, C. Théry*, G. Raposo*. (2013). Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci 126: 5553-5565.

A. Bobrie, S. Krumeich, F. Reyal, C. Recchi, L.F. Moita, M.C. Seabra, M. Ostrowski and C. Théry (2012). Rab27a supports exosome-dependent and –independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 72 : 4920-4930.

G. Sugano*, I. Bernard-Pierrot*, M. Laé, C. Battail, Y. Allory, N. Stransky, S. Krumeich, M.-H. Donnadieu, C. A. Abbou, S. Benhamou, T. Lebret, X. Sastre-Garau, S. Amigorena, F. Radvanyi and C. Théry (2011). Milk Fat Globule – Epidermal Growth Factor-Factor VIII / lactadherin promotes bladder tumor development. *equal contribution. Oncogene 30 : 642-653.

M. Ostrowski, N.B. Carmo*, S. Krumeich*, I. Fanget*, G. Raposo, A. Savina, C F. Moita, K. Schauer, A.H. Hume, R.P. Freitas, B. Goud, P. Benaroch, N. Hacohen, M. Fukuda, C. Desnos, M.C. Seabra, F. Darchen, S. Amigorena, L. Ferreira-Moita and C. Théry (2010). Rab27a and Rab27b control different steps of the exosome secretion pathway. Nature Cell Biol. 12 : 19-30.