EDELMAN Aleksander : UMR_S1151 UMR8253 : Epithelial channelopathies : cystic fibrosis and other diseases

Unit : INSERM UMR_S1151 - CNRS UMR8253 - Institut Necker Enfants Malades (INEM) - Université Paris Descartes

INSERM UMR_S1151 - CNRS UMR8253 - Institut Necker Enfants Malades (INEM) -
Université Paris Descartes
Bâtiment Leriche - porte 9
14 rue Maria Helena Vieira Da Silva CS 61431
75993 PARIS Cedex 14

Speciality : Department BCMPP

Director of the unit : Xavier NASSIF

Principal investigator :

EDELMAN Aleksander
Email : aleksander.edelmanSPAMFILTER@inserm.fr Phone number: +33 (0)1 72 60 64 10

Composition of research team :

  • EDELMAN Aleksander (DR1-CNRS, HDR)
  • SERMET-GAUDELUS Isabelle (PUPH, HDR)
  • URBACH Valérie (CR1-INSERM)
  • NGYEN-KHOA Thao (PH)
  •  COTTARD Charles-Henri (MCU-PA)

5 Recent publications of the research team :

Jeanson L, Kelly M, Coste A, Guerrera IC, Fritsch J, Nguyen-Khoa T, Baudouin-Legros M, Papon JF, Zadigue P, Prulière-Escabasse V, Amselem S, Escudier E, Edelman A.  Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. Allergy 2012, Mar;67(3):403-12.

Colas J, Faure G, Saussereau E, Trudel S, Rabeh WM, Bitam S, Guerrera IC, Fritsch J, Sermet-Gaudelus I, Davezac N, Brouillard F, Lukacs GL, Herrmann H, Ollero M, Edelman A. Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect. Hum Mol Genet. 2012 Feb 1;21(3):623-34.

Saussereau E, Roussel D, Diallo S, Debarbieux L, Edelman A and Sermet-Gaudelus I. Validation of nasal potential in CFTR knock-out and F508del-CFTR mice. PLoS One. 2013 2013;8(3):e57317. doi: 10.1371/journal.pone.0057317. Epub 2013 Mar 7.

Bakouh N, Bienvenu T, Thomas A, Ehrenfeld J, Liote H, Roussel D, Duquesnoy P,  Farman N, Viel M, Cherif-Zahar B, Amselem S, Taam RA, Edelman A, Planelles G, Sermet-Gaudelus I. Characterization of SLC26A9 in patients with CF-like lung disease. Hum Mutat. 2013 Oct;34(10):1404-14

Odolczyk N, Fritsch J, Norez C, Servel N, da Cunha MF, Bitam S, Kupniewska A,  Wiszniewski L, Colas J, Tarnowski K, Tondelier D, Roldan A, Saussereau EL, Melin-Heschel P, Wieczorek G, Lukacs GL, Dadlez M, Faure G, Herrmann H, Ollero M, Becq F, Zielenkiewicz P, Edelman A. Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain. EMBO Mol Med. 2013 Oct;5(10):1484-501. doi: 10.1002/emmm.201302699.