AIT-SI-ALI Slimane : UMR7216 : Epigenetics and Cell Differenciation

Unit : CNRS UMR7216 Epigénétique et Destin Cellulaire - Université Paris Diderot

Université Paris Diderot
CNRS UMR7216 "Epigénétique et Destin Cellulaire"
Bâtiment Lamarck 4ème étage 
Case courrier 7042
35, rue Hélène Brion
75205 PARIS Cedex 13

Speciality : Department BCMPP

Director of the unit : Jonathan WEITZMAN

Principal investigator :

AIT-SI-ALI Slimane
Email : slimane.aitsialiSPAMFILTER@univ-paris-diderot.fr Phone number: +33 (0)1 57 27 89 19

Composition of research team :

  • AIT-SI-ALI Slimane (DR2-CNRS, HDR))   
  • AMEYAR-ZAZOUA Maya (CR1-INSERM, HDR)
  • JOLIOT Véronique (MCF, HDR)

5 Recent publications of the research team :

Mozzetta C, Boyarchuk E, Pontis J and Ait-Si-Ali S. Sound of Silence: The properties and functions of repressive lysine methyltransferases. Nature Reviews Mol Cell Biology 2015 Aug;16(8):499-513.

Mozzetta C, Pontis J, Fritsch L, Robin P, Portoso M, Proux C, Margueron R and Ait-Si-Ali S. (2013). Methylation of Histone H3 Lysine 9 by G9a/GLP Regulates Polycomb Repressive Complex 2-Mediated Gene Silencing. Molecular Cell, 2014 Jan 23;53(2):277-89.

Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E and Harel-Bellan A.(2012 Oct). Argonaute proteins couple chromatin silencing to alternative splicing. Nature Structural and Molecular Biology;19(10):998-1004.

Joliot V, Ait-Mohamed O, Battisti V, Pontis J, Philipot O, Robin P, Ito H, Ait-Si-Ali S. The SWI/SNF subunit/tumor suppressor BAF47/INI1 is essential in cell cycle arrest upon skeletal muscle terminal differentiation. PLoS One 2014 Oct 1;9(10):e108858.

Guasconi V, Pritchard LL, Fritsch L, Mesner LD, Francastel C, Harel-Bellan A and Ait-Si-Ali S. (2010 Nov-Dec). Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells. Epigenetics 2010 Nov-Dec;5(8):704-9.

Fritsch L, Robin P, Mathieu J, Souidi M, Hinaux H, Rougeulle, Harel-Bellan, Ameyar-Zazoua M and Ait-Si-Ali S. A Subset of the H3K9 Methyltransferases Suv39h1, G9a, GLP and SETDB1 Participate in a Multimeric Complex. Molecular Cell 2010, 15;37(1):46-56.